Indian Journal of Research in Homoeopathy


Homoeopathy, Homoeopathic pathogenetic trial, Drug proving, Hygrophila spinosa, Pathogenetic effects

Article Type

Original Article


Objective: The study was conducted to elicit the pathogenetic response of Hygrophila spinosa in homoeopathic potencies on healthy human volunteers. Methodology: The drug Hygrophila spinosa was proved by the Central Council for Research in Homoeopathy (CCRH) through randomized, double-blind, placebo-controlled method. The proving was conducted at three centres viz. Central Research Institute (H), [CRI (H)] Noida, Drug Proving Unit [DPU], Bhubaneswar and Regional Research Institute (H) [RRI (H)], Kolkata. The drug was proved in two potencies (6C and 30C) on 48 apparently healthy volunteers who were selected after conducting pre-trial medical examinations by the medical specialists and routine laboratory investigations. 32 of them where kept on interventional drug trial and remaining took placebo. At CRI (H), NOIDA, 56 dose schedule (i.e. 56 doses of drug/placebo were consumed in each batch) was followed while at DPU, Bhubaneswar and at RRI (H), Kolkata, 12 dose schedule (i.e. 12 doses of drug/placebo were to be consumed in each batch) was followed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the Proving Masters which were compiled at Homoeopathic Drug Proving-cum-Data Processing cell of CCRH headquarters after decoding. Results: Out of 32 provers who were on interventional drug trial, only 14 manifested symptoms. The drug was able to produce symptoms in both the potencies. 92 symptoms appeared during the drug trial from various locations. Conclusion: The drug pathogenesis evolved indicates its therapeutic use for urticaria, frontal sinusitis, conjunctivitis, stomatitis, gastroenteritis, nausea (morning sickness), intermittent fever etc.

Digital Object Identifier



Wolters Kluwer India Pvt. Ltd.



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