Indian Journal of Research in Homoeopathy


Centesimal potency, Homoeopathy, Influenza like illness, LM potency, Placebo, Randomized trial

Article Type

Original Article


Background: In the past decade the upsurge of influenza throughout the globe was significant and in recent years this has resurfaced showing failures of all the preventive and therapeutic measures against it. Thus, this study was undertaken to evaluate the effect of homoeopathic medicines in the treatment of Influenza like illness (primary objective) and to compare the complication rate among patients receiving homoeopathic medication as compared to the patients receiving placebo and also to compare the efficacy of LM potency vis-ΰ-vis Centesimal potency (secondary objective). Material and Methods: This was a multicenter, prospective, randomized, triple arm placebo controlled trial conducted at nine Institutes and Units of Central Council for Research in Homoeopathy (CCRH) from June 2009 to December 2010. The patients fulfilling the inclusion criteria were randomized to LM, Centesimal and Placebo groups. Homoeopathic interventions were given as per the principles of homoeopathy. Symptoms of Influenza like illness (ILI) were assessed as per validated scales. Data analysis was done using statistical package of SPSS 20.0 version. Each symptom was compared for 10 days among the allocated groups by using Kruskal wallis test and bonferroni correction for the multiple comparisons. Results: Out of 739 screened cases, 447 cases were eligible for enrolment comprising of LM (n=152), (n=147) and placebo (n=148) cases. There was a significant difference in temperature from 2 nd day onwards in LM and Centesimal groups. The significant improvement was observed in headache and myalgia on 1 st day in both the treatment groups. Likewise, significant improvement was noted in malaise on 2 nd day in both the groups; sore throat on 1 st day in LM and 2 nd day in Centesimal; fatigue on 2 nd day in LM and on 3 rd day in Centesimal group; nasal complaints on 2 nd day in LM and 1 st day in Centesimal group; chill on 3 rd day in LM group and 1 st day in Centesimal group and in sweat on 1 st day in the treatment groups. Cough improved significantly from 3 rd day in both the groups. Conclusion: The study revealed the significant effect of individualized homoeopathic treatment in the patients suffering from ILI with no significant difference between LM and Centesimal groups. The complication/sequel rate was also significantly less in the intervention groups.

Digital Object Identifier



Wolters Kluwer India Pvt. Ltd.



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