Safety of potentised dilutions of Rhus toxicodendron in Wistar albino rats

Authors

Abanti Goswami, Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata, West Bengal, IndiaFollow
Narasimha Kumar GV, Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata, West Bengal, IndiaFollow
Vara Prasad Saka, Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata, West Bengal, IndiaFollow
Pankaj Gupta, Dr DP Rastogi Central Research Institute for Homoeopathy, Noida, Uttar Pradesh, IndiaFollow
Bibaswan Biswas, Central council for Research in Homoeopathy, New Delhi, IndiaFollow
Digvijay Verma, Central council for Research in Homoeopathy, New Delhi, IndiaFollow

Author ORCID Identifier(s)

Abanti Goswami- https://orcid.org/0000-0003-2208-6602

Narasimha Kumar GV - https://orcid.org/0000-0003-4991-1932

Vara Prasad Saka-https://orcid.org/0000-0002-2778-8630

Pankaj Gupta - https://orcid.org/0000-0003-3896-7869

Bibaswan Biswas - https://orcid.org/0000-0003-3654-298X

Digvijay Verma- https://orcid.org/0000-0003-1903-1125

Corresponding Author

Narasimha Kumar GV

Keywords

Acute toxicity, Homoeopathy, Organisation for Economic Cooperation and Development, Rhus tox., Safety, Subacute toxicity

Article Type

Original Article

Abstract

Background: Rhus toxicodendron (Rhus tox.) is a well-known homoeopathic medicine used to treat inflammatory disorders supported by historical and modern scientific evidence. Objective: The safety testing of 6C, 30C and 200C potencies of Rhus tox. through acute and sub-acute oral toxicity tests as per the Organisation for Economic Cooperation and Development test guidelines. Methods: For the acute oral toxicity study, Rhus tox. (2000 μL/kg) was administered to rats and observed for 14 days. For the subacute oral toxicity study, Rhus tox. (200 μL/kg) was administered for 28 days and additional recovery groups were included to monitor reversibility, persistence, or delayed occurrence of toxic effects for 14 days post-treatment. Histopathological assessments of vital organs were done to detect any signs of toxicity. Results: No mortality occurred during the acute toxicity study at a dose of 2000 μL/kg, indicating an oral LD50 of Rhus tox. >2000 μL/kg. In the sub-acute toxicity study, Rhus tox. administration for 28 days showed no adverse clinical signs, with normal weight gain and feed intake in treated animals. No adverse changes were noticed in the biochemical and haematological parameters of Rhus tox. treated rats. Furthermore, no abnormalities were observed in gross and histopathological examinations of vital organs. Conclusion: The study found that Rhus tox. in 6C, 30C and 200C potencies exhibited a safe toxicological profile, supporting its beneficial pharmacological effects.

Digital Object Identifier

10.53945/2320-7094.1864

Publisher

Central Council for Research in Homoeopathy

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

How to cite this article

Goswami A, GV N, Saka V, Gupta P, Biswas B, Verma D. Safety of potentised dilutions of Rhus toxicodendron in Wistar albino rats. Indian J Res Homoeopathy 2024;18(1):3-14. doi: 10.53945/2320-7094.1864