Indian Journal of Research in Homoeopathy

Corresponding Author

Roja Varanasi


Homoeopathy, chronic rhinosinusitis, radomized controlled trial, Sino Nasal Outcome Test -22, Total Symptoms Score.

Article Type

Original Article


Background: Chronic rhinosinusitis (CRS) is a significant health problem impacting health related quality of life.

Objectives: This study assesses the efficacy of individualised homoeopathy (IH) in LM potency in CRS.

Methods: A randomised, double-blind and placebo-controlled trial on patients with CRS was undertaken at four institutes, from July 2012 to December 2013. Eligible participants were randomised to IH in LM-potencies (n = 60) or a similar placebo (n = 60). Primary outcome was change in the total symptoms score (TSS) (area under the curve [AUC]) and in sinus nasal outcome test 22 over 3 months. Intention-to-treat approach was used for analyses.

Results: TSS AUC over 3 months was less in the homoeopathy group compared to the placebo group but was statistically insignificant (IH: 1303.1 ± 612.2; P = 1380.1 ± 811.8; 95% CI: −336.9, 182.9; P = 0.56). The absolute difference in TSS from baseline had a statistically significant difference at day 60 (mean difference = 4; 95% CI: 0.3–7.7, P = 0.03) and day 75 (mean difference =3.8; 95%: 0.1–7.5, P = 0.04) favouring homoeopathy. The global assessment by the investigator and patient showed satisfactory improvement at day 60 mean difference = 0.6, 95% CI: 0.27–0.86, P = 0.0001 and day 75 mean difference = 0.5, 95% CI: 0.27–0.84, P = 0.0001, respectively. A positive trend was observed in rhinoscopy score in homoeopathy group (mean difference: 0.9, 95% CI: −0.00–1.8, p=0.05). There was no difference in computed tomography scan scores of paranasal sinuses between the groups.

Conclusion: This study provides a positive trend to support the effect of individually selected homoeopathic remedies in patients with CRS and warrants further evaluation.

Digital Object Identifier



Central Council for Research in Homoeopathy

Included in

Homeopathy Commons








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