Indian Journal of Research in Homoeopathy

Corresponding Author

Dr Sithara Perveen


Gout, Hyperuricaemia, In vitro, Lycopodium clavatum, Monosodium urate crystal

Article Type

Original Article


Background: Hyperuricaemia plays a significant role in the development and pathogenesis of several metabolic and systemic disorders including metabolic syndrome, hypertension, stroke and atherosclerosis. Lycopodium clavatum is the most widely used drug in homoeopathy for treating hyperuricaemia and gout. However, its mechanism of action in reducing serum uric acid remains uncertain. Objective: The objective of the study was to study the potential role of homoeopathic preparation of Lycopodium clavatum in different potencies on monosodium urate crystallisation in vitro. Methods: Spectrophotometric crystallisation assay was carried out on a stock solution of 5 ml of uric acid after its preparation. The time course of the optical density was measured in a standard solution and values were measured every 5 min after agitation with cyclo-vortex mixer. The optical density values were also measured in the homoeopathic preparation of Lycopodium clavatum in different potencies with same method. Inhibiting effect of this medicine was found from graphs by measuring slope of nucleation and aggregation from optical density value and the percentage inhibition exerted by the proteins was calculated. Results: Spectrophotometric analysis showed all potencies of Lycopodium clavatum inhibited aggregation of monosodium urate crystals with a maximum inhibition at 200C and 1M potency. Conclusion: We found that the homoeopathic medicine Lycopodium clavatum could be effective in inhibiting the formation of monosodium urate crystals in vitro and also causes the dissolution of crystals, especially in high potencies. Further studies are required to understand the exact mechanism of action.

Digital Object Identifier



Central Council for Research in Homoeopathy

Included in

Homeopathy Commons








To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.