Lycopodium clavatum for the management of urolithiasis: A randomised double blind placebo controlled trial

Authors

Rupali Bhalerao, Central Council for Research in Homoeopathy, New Delhi
Oberai Praveen, Central Council for Research in Homoeopathy, New Delhi
Pritha Mehra, Dr. D. P. Rastogi Central Research Institute of Homoeopathy, Noida, Uttar Pradesh
Yogendra Rai, Dr. D. P. Rastogi Central Research Institute of Homoeopathy, Noida, Uttar Pradesh
Gurudev Choubey, Clinical Research Unit (H), Siliguri, West Bengal
Amulya Sahoo, Drug Proving Unit, Bhubaneswar, Odisha
A Majumder, DAC Regional Research Institute of Homoeopathy, Kolkata, West Bengal
Mahesh Sah, Homoeopathic Drug Research Institute, Lucknow, Uttar Pradesh
A Gupta, Regional Research Institute (H), Shimla, Himachal Pradesh

Keywords

Calculi, Colic, Homoeopathy, Lycopodium clavatum, Non-steroidal anti-inflammatory drug, Urolithiasis

Article Type

Original Article

Abstract

Background: Urolithiasis is the most common disease of urinary tract found worldwide. There are several approaches for the treatment of urolithiasis that include the use of various synthetic and natural drugs and/or surgery in the conventional system of medicine. Objective: This study was taken up to evaluate the efficacy of Lycopodium clavatum in the management of urolithiasis. Materials and Methods: A multicentric, randomised, double-blind, placebo-controlled trial was conducted. Patients having symptomatology like Lycopodium clavatum were enrolled after screening and repertorisation as per the inclusion and exclusion criteria. During acute renal colic, despite group allocation, the patients were either prescribed the indicated homoeopathic medicines or conventional medicine. The analysis was carried out with an intention-to-treat approach, and missing values were handled using Last Observation Carry Forward method. Results: There was no statistical significance between the groups (P = 0.31) in reference to the number of cases in which stones expelled during the trial. The mean size of single stone expelled was 9.4 ± 4.9 and 13.9 ± 2.2 in Verum and Placebo groups, respectively (P= 0.12). There was also no significant difference in the mean size of mean size of multiple stones; in Verum group (10.1 ± 5.3) and Placebo group (16.1 ± 9.1) (P = 0.11). For assessment of pain and dysuria, Visual Analogue Scale was used, and a statistically significant difference was found between the groups (P = 0.039) for pain, and positive trend for Homoeopathy was noted for dysuria. A verified symptom syndrome of Lycopodium clavatum has been observed. Conclusion: Future studies with pragmatic study design and individualistic Homoeopathy can be undertaken to assess the effectiveness of treatment in urolithiasis.

Digital Object Identifier

10.4103/ijrh.ijrh_30_19

Publisher

Wolters Kluwer India Pvt. Ltd.

How to cite this article

Bhalerao R, Praveen O, Mehra P, et al. Lycopodium clavatum for the management of urolithiasis: A randomised double blind placebo controlled trial. Indian J Res Homoeopathy 2019;13(3):139-149. doi: 10.4103/ijrh.ijrh_30_19