•  
  •  
 

Indian Journal of Research in Homoeopathy

Keywords

Haemocompatibility, Homoeopathy, nanomedicine

Article Type

Original Article

Abstract

Background: The objective of the study was to characterize homoeopathic nanomedicine Aurum metallicum and evaluate its biocompatibility, to explore its possible application as injectables. Metal-based homoeopathic medicine, Aurum metallicum, was chosen as a model drug and the haemocompatibility of the drug at three different potencies 6C, 30C, and 200C were studied to find the justification of the drug as an injectable candidate for clinical application. Methods: The model drug Aurum metallicum at the three potencies was characterized by dynamic light scattering (DLS), zeta potential, field emission scanning electron microscopy (FESEM), and energy dispersive X-ray analysis. Hemocompatibility of the homoeopathic medicine was performed by haemolysis assay. Red blood cell obtained from fresh human blood by centrifugation was incubated with Aurum metallicum. Haemoglobin release was measured using UV-vis spectrophotometer at 540 nm. Results: The DLS and FESEM studies show a decrease of particle size with increasing potency. The zeta potential values show a fairly constant value measured at an interval of 10 days. The haemolysis percentage for 6C, 30C, and 200C was 9.73%, 8.16%, and 0.73%, respectively. Conclusion: The nanomedicine Aurum metallicum was nontoxic at all doses of 6C, 30C, and 200C. The haemolytic percentage also shows that 200C is nonhemolytic, showing haemolysis <2% as per the American Society for Testing and Materials guidelines. The undertaking of larger controlled and in-depth qualitative studies is warranted.

Digital Object Identifier

10.4103/0974-7168.200847

Publisher

Wolters Kluwer India Pvt. Ltd.

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.