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   2008| October-December  | Volume 2 | Issue 4  
    Online since April 14, 2014

 
 
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EXTRA MURAL RESEARCH
Immunological studies on Rheumatoid Arthritis treated with Homeopathic drugs: Results of the Pilot Study
Prakash Rao, M Nagalakshmi Prasanna
October-December 2008, 2(4):42-49
Introduction & Objective: Rheumatoid Arthritis (RA), a systemic disease, is characterized by a chronic inflammatory reaction in the synovium of joints. The inflammation is mediated by inflammatory cytokines. The objective of the study was to evaluate efficacy of homeopathic drugs and changes in the cytokine profile of rheumatoid arthritis patients treated with homeopathic drugs. Materials and Methods: A total of 35 rheumatoid arthritis patients and 10 healthy controls completed this pilot study. The patients were treated with Rhus tox. (8), Pulsatilla (8) and Medorrhinum (9) according to totality of symptoms. The control group (10) received placebo. The patients were evaluated for disease activity at the time of enrollment in the study and after 3 weeks of therapy. Serum cytokine levels (IL-1α, IL-1β, IL-2, IL-6 and TNF-α) were measured at baseline and after 3 weeks of treatment. Result: Patients receiving Rhus tox. showed significant improvement in Patient Visual Analogue Score (VAS) for global assessment of disease after 3 weeks of therapy compared to placebo group( p = 0.03). Patients receiving Pulsatilla showed a significant improvement in tender joint count (p = 0.01) at the end of 3 weeks compared to baseline. They also showed significant decrease in ESR (p = 0.02) as compared to placebo. However, hs-CRP values in treatment groups did not show significant difference when compared to the placebo group at baseline and after therapy. There was a significant decrease in IL 6 levels after 3 weeks of therapy in the patients treated with Rhus tox. and Medorrhinum compared to placebo (p=0.05 and 0.04 respectively). Surprisingly, there was a significant increase in IL 6 level in the placebo group compared to their baseline values (p = 0.04), suggesting ineffectiveness of placebo and worsening of the disease process. Conclusion: In the present open label placebo controlled pilot study patients treated with 3 weeks of homeopathic drugs showed improvement in clinical features, reduction in parameters of inflammation and IL6 levels. These observations suggest a possible immunomodulatory role of homeopathic drugs in Rheumatoid Arthritis which need to be confirmed by further studies.
  2,189 427 -
CASE RECORD
A big urinary calculus expelled with homoeopathic medicine
AK Gupta, Jaya Gupta, VA Siddiqui, Alok Mishra
October-December 2008, 2(4):50-55
Urinary stones of up to 5 mm. of diameter are known to pass spontaneously through the urinary tract, whereas those exceeding 7 mm. of diameter almost always require surgical intervention. A case of 16.9 mm calculus, lodged close to left uretero-vesicular junction, presented with severe cramping pain in the left lumbar region, which radiated downwards to the groin area. Patient also had severe pain at the end of urination. After analysing the totality of symptoms presented by the patient, Sarsaparilla 30C was prescribed. Three doses of this homoeopathic medicine could expel the stone, without causing considerable discomfort or bleeding.
  1,747 384 -
CLINICAL VERIFICATION
Mentha piperita – A Multicentric Clinical Verification Study conducted by CCRH
PS Chakraborty, JP Singh, MK Rai, Pramodji Singh, AK Vichitra, A.K.N. Singh, Deepa Chakraborty, DK Singh, Hari Singh, Mohan Singh, MN Sinha, Rajpal , RK Rai, S Prakash, SD Pathak, SR Bhagat, Vikram Singh, Vijay K Paul, VK Singh, Yogendar Rai, VA Siddiqui
October-December 2008, 2(4):26-33
Mentha piperita has been used in Homoeopathy for many conditions like dry and spasmodic cough, hoarseness of voice, husky voice, productive cough, tendency to catch cold, headache, painful throat, infantile colic, pruritus vulvae, pain in neck, pimples on face, herpetic eruptions, etc as found in the literature. Besides these, pharyngitis, vertigo, coryza, tracheitis, gastritis, constipation and Urticaria were also relieved by this medicine and thus unfolding the hidden character of the medicine in there clinical conditions during the study. A total of 6372 patients participated in this multicentric clinical verification study at various Units/Institutes under Central Council for Research in Homoeopathy to confirm the symptom of Mentha piperita, as mentioned in the homoeopathic Materia Medica.
  1,593 299 -
CLINICAL RESEARCH
Clinical evaluation of homoeopathic therapy in the management of hyperlipoproteinemia
JP Govekar, VK Paul, K Singh, Praveen Oberai, Varanasi Roja
October-December 2008, 2(4):34-41
Objectives: This study aimed at evolving a group of useful homoeopathic medicines in the treatment of hyperlipoproteinaemia, to identify their reliable indications, most useful potencies, frequency of administration and relationship with other medicines. Methods: A prospective observational study was carried out during the period 1992-2003. Three hundred and twenty two patients with hyperlipoproteinaemia and various clinical presentations were studied. Patients of more than 30 years of age, with cholesterol > 200mg/dl, triglycerides > 170mg/dl, LDL > 150mg/dl, VLDL > 50mg/dl and HDL < 35 mg/dl were included in this study. Specific parameters were followed to assess the intensity of complaints and the improvement status. Homoeopathic medicines were prescribed in different potencies (Q to 10M), basing on the presenting complaints, mental and physical attributes of the patients. The patients were advised to have low calorie diet and regular exercise. Results: Two hundred ninety three (293) patients were followed up regularly and varying degrees of improvement were observed, viz. marked improvement in 77 patients, moderate improvement in 113 patients, mild improvement in 100 patients and no improvement in 03 patients. Abroma augusta 30, Gelsemium 30, Lycopodium 1M, Bryonia alba 30, Pulsatilla 30, Nux vomica 30 were found to be useful among the other prescribed medicines. Conclusion: Results obtained from the study are encouraging with findings that 26% of the patients improved markedly with an evidence of changes in laboratory parameters. However, an experiment in controlled setting with improved protocol and clearer outcome parameters is required.
  1,447 344 -
DRUG STANDARDISATION
Ultra Dynamised and Undynamised Dilutions of Alloxan at Micro-doses Influence Selective Pancreatic Beta Cell and Hormonal Profile: An Experimental Approach
Sunil Kumar, C Nayak
October-December 2008, 2(4):10-19
Dynamised and Undynamised preparations of Alloxan 6x, 30x, 200x, and 1000x were examined for its anti-diabetic activities in Alloxan induced diabetes mellitus albino rats. Oral administration of dynamised potencies of Alloxan 6x, 30x, 200x, and 1000x at dose level of 50μ1/100 g.b.w. daily for 30 days regularly exhibited slow and steady fall in blood sugar level accompanied with perceptible increase in serum growth hormone (GH) i.e. p < 0.01 (less significant) and p < 0.001 (significant) respectively when compared to dynamised and Undynamised control as well as Undynamised Alloxan fed groups under identical conditions. Histological and histo-morphometric studies also revealed reactivation of Pancreatic β-cells. Dynamised dilutions of Alloxan acts steadily through hypothalamo-hypophysial- pancreatic β-cells axis producing selective reactivation of β-cells at micro-doses, steadily viz 6x < 30x < 200x < 1000x. The drug may indirectly release Releasing factors (RF) from hypothalamic neurons, stimulating the secretion of growth hormone which in turn triggers optimum insulin secretion from β-cells. The therapeutic action of the test drug in dynamised dilutions at micro dose and relatively high dilutions on pancreatic β-cells confirms the phenomenon of "Potentization" & "Similia Similibus Curentur" and lack of acute and sub-acute toxicity at fairly large dosage may open up new prospects in the treatment of diabetes mellitus and throw light in elucidating the mechanism of action at higher dilutions. It was noticed that the dynamised dilutions of alcohol fed control group is more toxic and lethal to animals than the dynamised and Undynamised dilutions of Alloxan and Undynamised alcohol fed control groups. Furthermore, it was also discernible that blood sugar and growth hormone levels were stabilized even after withdrawal of test drug in its 30x, 200x and 1000x potencies.
  1,434 229 -
DRUG PROVING
Paraffin: A Multicentric double blind Homoeopathic Pathogenetic Trial carried out by CCRH
Rajpal , VA Siddiqui, NR Dey, KC Das, Yogendra Rai, Vinay Kr Singh
October-December 2008, 2(4):20-25
Objective: Objective of the study was to elicit the pharmacodynamic response of the drug Paraffin on healthy human volunteers in non-toxic doses. Methodology: Drug was proved through a double-blind method and multi-centric study. Trial drug was proved in three potencies (6C, 30C and 200C) on 43 volunteers who were declared apparently healthy during their pre-trial medical examination by medical specialists. The volunteers consumed 56 doses (four doses per day for fourteen days) of each potency (6C, 30C and 200C) in three stages for a varying period. The symptoms generated during the trial period were noted by the volunteers and elaborated and cross examined by the Proving Masters. The data obtained from different centers were compiled at proving-cum-data processing cell at CCRH headquarters after de-coding. Observation: Out of the 30 provers who were on actual drug trial, 13 manifested symptoms. Drug was able to produce symptoms in each potency more or less on every part of the body. Only a few symptoms appeared in more than one prover. Some of the symptoms have been reproved which are mentioned in the fragmentary provings published in different literature. Conclusion: Pharmacodynamic response is elicited from every part of the body. Symptoms appeared (new and reproved) during the proving trial will add to the literature available on the drug and benefit the research scholars and clinicians. The symptoms need to be verified through clinical application in different clinical conditions.
  1,386 222 -
FUNDAMENTAL RESEARCH
Modeling Physical-Chemical Properties of High Dilutions: an electrical conductivity study
Carla Holandino, Rafael Harduim, Venício Feo da Veiga, Sheila Garcia, Carlos Renato Zacharias
October-December 2008, 2(4):1-9
The most common way to perform succussions is to place a liquid preparation inside a glass vessel and beat it vigorously against a hard elastic surface, either manually or using a mechanical apparatus. This procedure has been assumed able to transfer mechanical energy to the molecular level, where it becomes available to perform chemical work. Such interpretation has been enforced by observed changes in the electrical conductivity (EC) of High Dilutions (HD) due to succussion. In order to address this question, we compared the electrical conductivity changes of HD prepared from Vincristine sulfate (VCR) samples with those of an inert solvent. Samples were produced through manual and mechanical succusions in order to observe the influence of bubbles production. The results confirmed the timing of EC changes but these were equivalent for VCR and solvent, except for VCR 1cH samples. Also, the production of bubbles does not affect the EC in an extent able to distinguish succussion procedures. We concluded that the physical-chemical properties of HD can be modeled by chemical and diffusive mechanisms typical of distilled water.
  1,309 249 -
EDITORIAL
Editorial
C Nayak
October-December 2008, 2(4):0-0
  1,019 151 -
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