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Alcoholic extract of potentised Catharanthus roseus (L.) G. Don. was evaluated for its anti-leukemic activity in in-vitro model. For this in- vitro study two cell lines namely, jurkat and K562 for promyelocytic leukemia and chronic myeloid leukemia were used. The cell lines were grown in Roswell Park Memorial Institute Medium (RPMI 1640 medium) containing 10% fetal bovine serum and 2mM L-glutamine. Doxorubicin (Adriamycin, ADR) was used as positive control drug. Growth inhibition of 50 % (GI50) was calculated from [(test growth in the presence of drug at the four concentration levels Ti - time zero Tz)/( control growth C-Tz)] x 100 = 50], which is the drug concentration resulting in a 50% reduction in the net protein increase in control cells during the drug incubation. The drug concentration resulting in total growth inhibition (TGI) was calculated from Ti = Tz. The LC50 (concentration of drug resulting in a 50% reduction in the measured protein at the end of the drug treatment as compared to that at the beginning) indicating a net loss of cells following treatment is calculated from [(Ti-Tz)/Tz] x 100 = -50 in sulforhodamine B (SRB) assay. The Catharanthus roseus in 2X potency showed maximum anti-leukemic activity in molar drug concentration of 20 μg/ml on human leukemic cell line K562 for chronic myeloid leukemia.

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Background: The action of homeopathic medicines, in ultra-high dilution, is not directly observable. An attempt was made to explore autonomic response of selective homeopathic medicines, in healthy persons, using Medical Analyzer System (Electronics Division, Bhabha Atomic Research Centre, Mumbai, India). Objective: The objective of the study was to observe the action of homeopathic medicines on physiologic variability of heart rate and blood flow. Material and methods: Pre- and postinterventional variability spectra of heart rate and blood flow of 77 subjects were recorded with the Medical Analyzer System, administering homeopathic preparations of Aconitum napellus (6c, 10M), Arsenicum album (200c, 1M), Gelsemium sempervirens (200c, 1M), Phosphorus (200c, 1M), Pulsatilla nigricans (200c) and Sulphur (200c, 1M) versus placebo control. The amplitude of the peaks viz. low-frequency, medium-frequency, and high-frequency was measured for postintervention analysis. An increase in the amplitude of any valid peak by 100% or a decrease by 50% was considered as significant change. Results: Aconitum napellus produced a response in heart rate variability (HRV) with 30c potency and in blood flow variability with 1M potency. Sulphur 200c and 1M, Gelsemium 200c and Pulsatilla 200c, produced a 62.5% response in HRV against the placebo response of 16.6%. Gelsemium, Phosphorus, and Sulphur produced a response in blood flow variability with a 1M potency, similar to the response of Aconitum napellus 1M. Conclusions: These data suggest that it is possible to record the response of homeopathic medicines on physiologic parameters of the autonomic nervous system.

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A case of multiple urinary calculi, with size varying from five to seven millimeters in the left kidney and four to six millimeters in the right kidney, a thirteen millimeter stone in the left lower part of the ureter and a 20 x 13 millimeter stone in the base of the urinary bladder presenting complaints of burning micturition and pain in the lumbar region reported at the O.P.D of the Central Research Institute for Homoeopathy at Kottayam, Kerala. Patient was having urolithiasis complaints since four years and had undergone both allopathic and ayurvedic treatment, but the response was not satisfactory. After repertorisation, Nitric acid 30C was prescribed. Two doses of this homoeopathic medicine proved to be effective.

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Objective: To elicit the pathogenetic response of the drug Bacopa monnieri in homoeopathic potencies on healthy human beings. Methodology: Drug Bacopa monnieri was proved by the Central Council for Research in Homoeopathy through randomized, double-blind, placebo-controlled method. The study was conducted at two centers. The drug was proved in three potencies (6C, 30C and 200C) on 32 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next three phases 56 doses (04 doses per day for 14 days) of each potency or placebo were consumed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the Proving Masters. The data obtained from both the centers was compiled at provingcum- data processing cell at CCRH headquarters after de-coding. Observations: Out of the 20 provers who were on actual drug trial, 07 manifested symptoms. Drug was able to produce symptoms in all three potencies more or less related to every part of the body. Conclusion: The pathogenetic responses elicited during the proving trial expands the scope of use of the drug Bacopa monnieri and will benefit the research scholars and clinicians. These symptoms will carry more value when verified clinically.

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Lactuca sativa L. is an erect, annual herb belonging to the family Asteraceae. The leaves are useful in angina pectoris, ascitis, asthma, constipation, cough, diarrhea, hysteria, gonorrhoea, affections of liver and spleen and pain in pylorus and spinal cord. Leaves are long, thin, orbicular or oblong, obovate, crisp and radical. The trichomes are uniseriate filiform capitate, uniseriate macroform conical and biseriate filiform capitate types; mesophyll is undifferentiated; laticiferous ducts and prismatic crystals are present in ground tissue; midvein bundle is bicollateral. The powder microscopic and organoleptic characters are provided. Physico-chemical parameters of raw drug viz., extractive values, ash values, formulation, besides weight per ml., total solids, alcohol content along with thin layer chromatography (TLC) and ultraviolet spectroscopic (UV) studies have been undertaken for mother tincture for the first time.

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