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Table of Contents
July-September 2016
Volume 10 | Issue 3
Page Nos. -
Online since Thursday, August 11, 2016
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EDITORIAL
Best practices in Homoeopathic research
p. 163
Raj K Manchanda
DOI
:10.4103/0974-7168.188222
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ORIGINAL ARTICLES
Pharmacognostical and phytochemical evaluation of
Cactus grandiflorus
(L.) Britton and Rose
p. 167
Rajat Rashmi, Divya Mishra
DOI
:10.4103/0974-7168.188225
Background:
Cactus
grandiflorus
(L.) Britton and Rose, Family:
Cactaceae
is an evergreen shrub with creeping aerial roots, used in Homoeopathy for atheromatous arteries, angina pectoris, and constriction of heart muscles, endocarditis, and heart weakness due to arteriosclerosis. Flowering stems are used in the preparation of medicine.
Objective:
The pharmacognostic and phytochemical studies are carried out to facilitate identification of correct species and standardized raw materials.
Materials
and
Methods:
Pharmacognostic studies of stem of authentic samples of
Cactus
grandiflorus
(L.) Britton and Rose have been carried out according to Trease and Evans, 1983, and Youngken 1959. To determine physicochemical constants, Indian Pharmacopoeia, 1970, was consulted and preliminary phytochemical properties were studied as per methods described by Trease and Evans, 1983.
Results:
Stem available in segments of variable length and thickness, roundish structure with 5 or 6 ridges and furrows with aerial roots, isodiametric cavities in cortex containing mucilage; aggregates of acicular and rhomboidal calcium oxalate crystals scattered in parenchymatous region are the key identification characteristic. Thin layer chromatography of chloroform extract of mother tincture reveals five spots with blue and violet colors.
Conclusion:
The macroscopic, microscopic, physicochemical, and phytochemical analysis of the authentic raw material were indicative to establish the standards for ensuring quality and purity of the drug.
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A randomized comparative trial in the management of Alcohol Dependence: Individualized Homoeopathy versus standard Allopathic Treatment
p. 172
Raj K Manchanda, KR Janardanan Nair, Roja Varanasi, Praveen Oberai, R Bhuvaneswari, Rupali Bhalerao, M Gnnanaprakasham, Maya Padmanabhan, VA Siddiqui
DOI
:10.4103/0974-7168.188236
Objectives:
This study was undertaken to compare the effects of IH with standard allopathic (SA) treatment.
Methods:
A randomized controlled, open-label, comparative trial, was conducted, in which alcohol dependents were screened verbally using the CAGE scale. The participants 80 patients fulfilling the inclusion criteria were randomized either IH (
n
=40) or SA (
n
=40) and treated cum followed up for 12 months. The primary outcome was more than 50% reduction in the Severity of Alcohol Dependence Questionnaire [SADQ] rating scale at 12
th
month. Data analysis was done for both intention-to-treat (ITT) and per-protocol (PP) populations.
Results:
ITT analysis reflected 80% (
n
= 32) of the patients in IH and 37.5% (
n
= 15) of the patients in the SA responding to CI before 2.4 treatment with absolute difference was 42.5% (42.5 [95% confidence interval [CI]: 23.0, 61.6]) and estimated effect: 6.6 (95% C.I: 2.4, 18.2),
P
= 0.0002. A significant difference favoring IH was also observed in three out of four domains of WHO QOL-BREF. Statistically significant difference was found in the number of drinking days (median difference: −24.00; CI: −39.0-−8.0;
P
= 0.001) and number of drinks per drinking day (median difference: −6.3 [95% CI: −11.3-−1.9];
P
= 0.004), favoring IH. The results showed a similar trend in PP analysis. Medicines found useful were
Sulphur,
Lycopodium
clavatum,
Arsenicum
album,
Nux
vomica,
Phosphorus,
and
Lachesis.
Conclusion:
The results conclude that IH is not inferior to SA in the management of AD patients. More rigorous studies with large sample size are however desirable.
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Effect of Homoeopathic treatment on Activity of Daily Living (ADL) in Knee Osteoarthritis: A prospective observational study
p. 182
FF Motiwala, Tapas Kundu, Kamlesh Bagmar, Vijay Kakatkar, Yogesh Dhole
DOI
:10.4103/0974-7168.188238
Objectives:
To investigate the effect of individualized homoeopathic medicines in improving ADL by reducing pain, stiffness and limiting the disease progress.
Materials and Methods:
131 consecutive patients with OA of knee were recruited and followed up for minimum period of twelve months. Two orthopaedic surgeons diagnosed the disease based on clinical examination of the patients. Three trained homoeopathic physicians prescribed individualized homoeopathic simillimum and the patients were evaluated for pain on WOMAC Osteoarthritis Index LK3.1 (IK) survey form measuring pain, stiffness and ADL. The pain was also measured on Numerical pain rating scale for confirmation.
Result:
Individualized homoeopathic medicines prescribed as per law of similia improved the mean ADL from 35.85 to 19.08 (p- 0.0001). Mean pain on WOMAC Osteoarthritis Index survey form improved from 10.50 to 5.48 (p-0.0001). The mean pain score on NRS improved from 6.34 to 3.77 (p-0.0001) and the mean morning stiffness also improved from 4.55 to 2.18 (p-0.0001).
Conclusion:
Homoeopathic medicines have potential to improve the ADL of OA patients by reducing pain and stiffness and limiting progress of the disease without any adverse systemic effects and can safely be employed as a comprehensive health care therapeutics.
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An open-label pilot study to explore usefulness of Homoeopathic treatment in nonerosive gastroesophageal reflux disease
p. 188
Renu Mittal, Anil Khurana, MS Ghosh, Ramesh Bawaskar, Divya Taneja, Sandhya Kashyap, Raj K Manchanda
DOI
:10.4103/0974-7168.188240
Background
and
Aim:
Nonerosive gastroesophageal reflux disease or nonerosive reflux disease (NERD) is characterized by troublesome reflux-related symptoms in the absence of esophageal erosions/breaks at conventional endoscopy. There are a number of medicines cited in homoeopathic literature which can be used for treatment of symptoms such as heartburn and regurgitation. A pilot study was undertaken to explore usefulness of homoeopathic medicines in treatment of NERD.
Methodology:
In this study, 78 patients were screened and 34 were enrolled, having symptoms of heartburn and/or regurgitation at least twice a week, having a gastroesophageal reflux disease (GERD) symptom score of more than 4. Homoeopathic medicine was prescribed on the basis of presenting symptoms. Response to treatment was assessed on GERD symptom score, visual analog scale (VAS) for heartburn, and World Health Organization quality of life-BREF (WHO-QOL) questionnaire evaluated at baseline and at end of 8 weeks of treatment
. Results:
Significant difference was found in pre- and post-treatment GERD symptom score (8.79 ± 2.7 vs. 0.76 ± 1.8;
P
= 0.001) and VAS for heartburn (47.47 ± 19.6 vs. 5.06 ± 11.8;
P
= 0.001). Statistically significant improvement was seen in three domains of WHO-QOL score, i.e. psychological health, social relationship, and environmental domain.
Conclusion:
The findings are encouraging to open avenues for further studies on reflux disease.
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CONFERENCE REPORT
International convention on World Homoeopathy Day: Integrating Homoeopathy in health care delivery
p. 199
Anil Khurana, Bindu Sharma, Meenakshi Bhatia, Harleen Kaur
DOI
:10.4103/0974-7168.188241
An International Convention on World Homoeopathy Day was held to commemorate the 261
st
birth anniversary of Dr. Samuel Hahnemann on 9
th
-10
th
April 2016, at Vigyan Bhawan, New Delhi, India. The theme of the Convention was "Integrating Homoeopathy in Healthcare" for achieving Universal Health Coverage (UHC) as advocated by the World Health Organization (WHO). The Convention made for an ideal platform for extensive deliberations on the existing global scenario of Homoeopathy, with particular reference to India, strategy building and formulation of national policies for worldwide promotion, safety, quality, and effectiveness of medicines, evolving standards of education, international cooperation, and evidence-based practice of Homoeopathy. Organized jointly by Central Council for Research in Homoeopathy (CCRH), an autonomous research organization of Ministry of AYUSH, Government of India, and Liga Medicorum Homoeopathica Internationalis (LMHI), the Convention witnessed presentations of more than 100 papers during 21 technical sessions held in parallel in four halls, each named after homoeopathic stalwarts, viz., Hahnemann, Boenninghansen, Hering, and Kent.
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CASE REPORT
Evidence-based Homoeopathy: A case of corneal abscess
p. 206
Sandeep Sudhakar Sathye
DOI
:10.4103/0974-7168.188242
Corneal abscess is a circumscribed collection of pus within the layers of cornea. It is usually endogenous in origin and commonly found near the limbal blood vessels close to corneal margin. Treatment in modern medicine is use of local and systemic antibiotics. Homoeopathy has mentioned medicines for corneal abscess. A case reported was a female of 68 years of age suffering from symptoms of redness, dull pain, and foreign body sensation in the right eye and was diagnosed as corneal abscess. The homoeopathic medicine
Hepar sulphuris
200C was prescribed on the basis of pathology. Abscess was reduced considerably within 5 days and it was absorbed completely in 21 days. No recurrence of abscess was observed thereafter. Ocular photographs during follow-up visits have provided documentary evidence about the effectiveness of homoeopathic
Hepar sulphuris
200C in corneal abscess.
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REMINISCENCES
Learning from the past: Review of the Central Council for Research in Homoeopathy Quarterly Bulletin 1998 (volume 20) and 1999 (volume 21)
p. 211
Manjula Narang Kapoor
DOI
:10.4103/0974-7168.188243
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RESEARCH UPDATES
Research Highlights (July-September 2016)
p. 214
Reteka Sexena
DOI
:10.4103/0974-7168.188244
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BOOK REVIEW
Book review on "Homoeopathy for Common Diseases-Before Consulting A Doctor"
p. 217
Laxmikanta Nanda
DOI
:10.4103/0974-7168.188245
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