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Table of Contents
January-March 2020
Volume 14 | Issue 1
Page Nos. 1-76
Online since Thursday, April 9, 2020
Accessed 37,279 times.
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EDITORIAL
Building up the scientific evidence base of homoeopathy
p. 1
Anil Khurana
DOI
:10.4103/ijrh.ijrh_22_20
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ORIGINAL ARTICLES
Effects of individualised homoeopathic intervention in Stage I essential hypertension: A single-blind, randomised, placebo-controlled trial
p. 3
Roja Varanasi, Raju Kolli, Yogendra Rai, Dubashi Ramesh, R G. R. Kiranmayee, G Ravi Chandra Reddy, H Baig, Tejaswini Patole, Priyanka Srivastava, Rupali Bhalaerao, Anupriya Chaudhary, Arvind Kumar, V Sarathy, GR Jayasri, Garima Sachdeva, Saurabh Kumar Jain, Neha Sharma, Sucharitha Amsole, Amita Oinam, Praveen Oberai, Raj K Manchanda
DOI
:10.4103/ijrh.ijrh_93_19
Background:
Hypertension (HTN) is a leading risk factor for death and disability and responsible for over 1.6 million deaths in India. Clinical case reports, observational studies and randomised controlled trials show the effects of homoeopathic medicine in HTN.
Objectives:
The results of this study will add to the evidence of effectiveness of individualised homoeopathic medicine in Stage I HTN.
Methods:
A single-blind, randomised, placebo-controlled trial was undertaken from October 2013 to March 2018. The primary outcome measure was to evaluate the change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) every month for 3 months. Of 2127 patients screened, 217 patients who fitted the inclusion criteria were randomised to receive either homoeopathic Q potencies (or LM potencies) plus lifestyle modification (LSM) =116 or placebo + LSM = 101. LSM included physical activity and diet as part of the treatment regimen. Analysis was by intention to treat.
Results:
Repeated-measure ANOVA between the groups showed statistically significant difference (Wilk lambda 0.85,
F
= 12.12, df = 213,
P
= 0.0001), in both SBP and DBP favouring Individualised Homoeopathy (IH) along with LSM.
Post hoc
independent
t
-test showed a significant mean reduction in SBP (mean difference 7.12 mm Hg, 95% confidence interval [CI] 4.72–9.53,
P
= 0.0001) and DBP (mean difference 5.76 mm Hg, 95% CI: 4.18–7.23,
P
= 0.0001) favouring Homoeopathy plus LSM group.
Sulphur
(
n
= 24),
Natrum muriaticum
(
n
= 21),
Lycopodium
(
n
= 16),
Nux vomica
(
n
= 12) and
Phosphorus
(
n
= 10) were the most useful medicines.
Conclusion:
IH in LM potency along with LSM was found effective over placebo along with LSM in the patients suffering from Stage I HTN. Further trials in rigorous setting are warranted.
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Proposed interaction mechanism between medicine and the diseased cell in diluted homoeopathic medicine
p. 15
Bijay Krishna Chaudhuri, Biswadeep Chaudhuri
DOI
:10.4103/ijrh.ijrh_47_19
Background:
High-diluted homoeopathic medicines practically contain no medicinal molecules. The disease-curing mechanism of homoeopathic medicines has not yet been adequately understood. Acceptable knowledge of this mechanism is essential for further development of homoeopathic science.
Objectives:
The purpose of this article is to provide a phenomenological model to understand the interaction mechanism between homoeopathic medicines and the diseased cell (DC), which cure diseases with a view to build a conceptual framework that would facilitate subsequent clinical and theoretical investigations.
Methods:
We have proposed the formation of hydrogen bonded nano and micro clusters (NAM) during the preparation (succession) of homoeopathic medicines. NAM are composed of effective ionic charge (such as O
+
, H
+
and other ions) distribution patterns (CDPs). During the electrostatic interaction between CDP around NAM and that around DC, H
+
ion (proton) or other ion tunnelling takes place, which normalises the highly disordered (higher entropy) state of the CDP around DC to bring it to the normal state.
Results:
NAM is DC dependent. The entropy change around the DDP leads to information change, which is transmitted to the brain through neurotransmitters to complete the disease remediation process. Proton or ion tunnelling from NAM to DC is quantum mechanical in nature.
Conclusion:
A novel phenomenological model demonstrating the interaction between DC and homoeopathic medicines (NAM) has been proposed that cures the disease. Ion tunnelling, entropy and related information change (cells signalling) taking place during the healing process appeared to be associated with biological phenomena, yet to be fully developed.
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REVIEW ARTICLE
Homoeopathic drug proving researches (1996–2018): A scoping review
p. 24
Raj K Manchanda, Anil Khurana, Peter Fisher, Bhopal Singh Arya, Pritha Mehra, Subhranil Saha, Munmun Koley, Meenakshi Bhatia
DOI
:10.4103/ijrh.ijrh_32_19
Background:
A systematic review on homoeopathic pathogenetic trials (HPTs) from 1945 to 1995 was published in 2007, and the basic question whether the effect produced by homoeopathic drugs in healthy human volunteers is equivalent to placebo or otherwise remained unanswered. There is a need to take up another review of HPTs conducted in the last two decades, to assess the changes in the methodologies adapted and to assess whether the effects produced in apparently healthy volunteers is due to homoeopathic medicines in high dilutions or not.
Objective:
To seek, collect, review and describe HPTs published during 1996–2018.
Materials and Methods:
A comprehensive literature search, both electronic and manual, was done using search terms ‘homoeopathic drug proving’ and ‘homoeopathic pathogenetic trial’ with time constraint of 1996–2018 in English language. As per the inclusion and exclusion criteria, the papers were selected for extraction of data in the predefined extraction form.
Results:
One hundred and forty-seven eligible records (74 peer-reviewed [PR] and 73 non-peer-reviewed [NPR]) of HPTs of 214 drugs were identified and subjected to the extraction of data. Majority of the drug proving records were contributed by the Central Council for Research in Homoeopathy which included 86 records (24 PR and 62 NPR) with the data of 24 and 63 drugs, respectively, and by Riley, one book (NPR) with data of 68 drugs. Heterogeneity was encountered in all aspects – design, conduct, participants and outcome reporting.
Conclusion:
This preliminary study is the basis for data recovery and for the forthcoming program of systematic review and meta-analysis, which may include the HPTs published in other languages.
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CASE REPORTS
Holistic treatment of chronic myeloid leukaemia with adjuvant homoeopathic therapy: A case report
p. 50
RT Shaji Kumar
DOI
:10.4103/ijrh.ijrh_49_19
Introduction:
Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder of haematopoietic stem cell.
Case Summary:
This is a case of a 28-year-old female having CML for 1½ years, on regular allopathic medication. The patient was suffering from ulceration in the oral cavity, frequent offensive loose stools with melena and prolonged menstrual cycle with heavy bleeding for 3 weeks. After analysing the constitutional make-up of the patient,
Platinum metallicum
200C was prescribed. Over a period of 3 months, the patient reported improvement in weakness, nausea, sleeplessness, irritability, heavy menstruation, loose black stools and backache. Until the last follow-up while submitting this report, the patient was on the maintenance dose of Imatinib along with homoeopathic medication.
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Chronic Cholelithiasis treated with Homoeopathic medicine in 50
th
millesimal potency: A case report
p. 57
Amulya Ratna Sahoo, Madhusmita Patnaik, Nilima Khamari, Somyaranjan Sahoo
DOI
:10.4103/ijrh.ijrh_15_19
Introduction:
Cholelithiasis or gallstone disease is a very common problem worldwide. The prevalence is more in females than males. Although cholecystectomy is considered the gold standard treatment for symptomatic cholelithiasis, it has its own limitations, risks and post-operative complications. Here, an alternative system of medicine, especially Homoeopathy, plays an important role in treating cholelithiasis.
Case Summary:
A 32-year-old female patient presented with the symptoms of dull pain in the right hypochondrium, sour eructations and regurgitation of food. The ultrasonography (USG) report confirmed the presence of multiple stones in the gallbladder of varying sizes, from 3 mm to 11 mm. Although she was advised for cholecystectomy, she was reluctant to undergo any surgery. Detailed case was taken, case was analysed, totality was formed, repertorization was done and
Lycopodium
was prescribed in fifty millesimal potency. Her symptoms were alleviated within a short span of time, and USG reports revealed that there were no stones after 3 months of treatment. Homoeopathic medicine
Lycopodium,
selected on the basis of totality of symptoms, was found effective in this case.
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A case report of prurigo nodularis responsive to Homoeopathy
p. 64
Nidhi Mahajan, Deeksha Chaturvedi, Anita Alaria, Girendra Pal
DOI
:10.4103/ijrh.ijrh_37_19
Introduction:
Prurigo nodularis (PN) is a chronic, benign neurodermatitis. The exact cause is unknown. In majority, cases of PN do not have a complete resolution of the nodules even with treatment.
Case Summary:
Here, a diagnosed case of PN of an 18 year old female with a history of 1 year old eczematous lesion is presented. On the basis of the totality of symptoms, homoeopathic medicine
Natrium muriaticum
was prescribed and gradually the patient showed stable improvement in the domain of signs and symptoms and reached remission by the end of 4 months. There was no recurrence over the next 1 year. This case report evidently suggests that Homoeopathy can serve as a possible treatment option for the management of PN cases.
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RESEARCH UPDATES
Research highlights (October 2019–December 2019)
p. 70
Anjula Narang
DOI
:10.4103/ijrh.ijrh_11_20
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BOOK REVIEW
An update on bowel nosodes with comparisons
p. 73
Laxmikanta Nanda
DOI
:10.4103/ijrh.ijrh_98_19
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OBITUARY
Obituary: Dr. Ramanlal Prabhudas Patel
p. 75
Suhana Panaparambil Azis
DOI
:10.4103/ijrh.ijrh_10_20
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Online since 05 July, 2013