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   Table of Contents - Current issue
Coverpage
January-March 2021
Volume 15 | Issue 1
Page Nos. 1-73

Online since Wednesday, March 31, 2021

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EDITORIAL  

Are we at the crossroads for integrative medicine? p. 1
Anil Khurana
DOI:10.4103/ijrh.ijrh_14_21  
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ORIGINAL ARTICLES Top

Evaluation of Hypericum perforatum mother tincture as an antigingivitis agent in comparison with Chlorhexidine: A randomised controlled trial p. 3
Swet Nisha, Debanjan Das, Paromita Goswami, Shashi Shekhar Shitanshu, Pratibha Shashikumar, Savan Sunari Rajaram
DOI:10.4103/ijrh.ijrh_49_20  
Background: Homoeopathic medicine Hypericum perforatum (Hyper.) has antimicrobial, wound healing and anti-inflammatory activity. It has been used as an analgesic postextraction, for nerve pain, burning mouth syndrome singly, or in combination with other Homoeopathy medications. Objective: Evaluation of the efficacy of Hyper. Q in reducing dental plaque and gingival inflammation. Materials and Methods: Three hundred and eighteen participants with chronic gingivitis (probing depth ≤ 3 mm) and bleeding gums were recruited and allocated randomly into three groups (n = 106 each): Group A (saline mouthwash), Group B (Hyper.) and Group C (Chlorhexidine [CHX]). Clinical parameters: Plaque index (PI), gingival index (GI), sulcus bleeding index (SBI) and oral hygiene index simplified (OHIS) were measured at baseline, first, third and sixth month. Results: All the three groups showed a statistically significant reduction in the PI, GI, SBI and OHIS (P < 0.05) at 3 months. Intergroup comparison showed significant reduction in PI, GI, SBI and OHIS (P < 0.05) in Group C compared to Groups A and B. Group B showed a statistically significant reduction in all clinical parameters when compared to Group A (P < 0.05) after 3 months. At 6 months, all the groups showed statistically significant reduction (P < 0.05) in all the clinical parameters; however, intergroup comparison did not show significant difference (P > 0.05). Conclusion: The present study demonstrated that the use of Hyper. Q as mouthwash significantly reduces plaque and gingival inflammation as compared to saline as mouthwash. However, CHX was found better than Hyper. Future research on use of Hyper. Q, dosage, substantiality and antimicrobial properties is warranted for its potential clinical use.
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Homoeopathic treatment of women with polycystic ovarian syndrome: A prospective observational study p. 12
Girish Gupta, Naveen Gupta, Santosh Singh, Varanasi Roja, Deepti Dewan
DOI:10.4103/ijrh.ijrh_12_20  
Background: Polycystic ovarian syndrome (PCOS) is one of the most common hormonal disorders among women of reproductive age group and a leading cause of female sub-fertility. Objectives: This study was conducted to evaluate the effect of individualised homoeopathy on clinical and hormonal profile in women suffering from PCOS. Materials and Methods: A prospective, observational study was conducted from July 2015 to June 2017 at Homoeopathic Research Foundation, Lucknow, in which 80 cases were screened, and 38 cases fulfilling the eligibility criteria were enrolled. Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ) was used to evaluate the quality of life. Serum levels of follicle-stimulating hormone, luteinising hormone, progesterone, prolactin, estrogen, testosterone and insulin were tested at the baseline and 12 months of treatment. Eighteen patients completed the follow-up of 12 months. The analysis was done with 'modified Intention to Treat' approach. Results: The comparison of PCOSQ from baseline to 12 months in 34 patients using the paired t-test showed significant improvement in the overall PCOSQ of the patients (mean increase ± standard error: −2.3 ± 0.5; 95% confidence interval CI: -3.2 to -1.3 P = 0.001). The number of cysts in both ovaries reduced with a statistically significant difference. There was a mean reduction of two cysts on each side of the ovary. The most prescribed medicines were Calcarea carbonica (38.24%) and Lycopodium. (26.47%) accounting to 64.71% of the total medicines. Conclusion: The present study gives positive leads in the management of PCOS with Homoeopathic medicines. Controlled trials are further warranted.
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An in vitro study of Hydrangea arborescens, homoeopathic preparation as an inhibitor of Calcium oxalate crystallisation p. 24
Rupali Amar Telang
DOI:10.4103/ijrh.ijrh_63_19  
Background: Homoeopathic mother tincture Hydrangea arborescens (Hydrang.) is conventionally used for urinary complaints, such as urinary tract infection, renal stones and prostate hypertrophy. However, the mode of its action for annihilation of complaints remains uncertain. This study was designed to investigate in vitro effect of homoeopathic preparations of Hydrang. on urolithiasis (Calcium oxalate [CaOx] crystallisation). Objective: To analyse the role of Hydrang. a, homoeopathic preparation in an in-vitro CAOx crystallisation. Materials and Methods: Spectrophotometric crystallisation assay was carried on and the slopes of nucleation and aggregation phases were calculated using linear regression analysis, and the percentage inhibition exerted by the Hydrang. Q, 6C, 30C and 200C was calculated. Microscopic observations of crystals of CaOx were carried out in the presence and in the absence of Hydrang. Q, 6C, 30C and 200C to support the spectrophotometric crystallisation assay. Results: The crystallisation studies performed indicate Hydrang. to be a potent medicine against CaOx crystallisation both at the level of nucleation and aggregation. Hydrang. Q favours aggregation to a great extent by showing the inhibition of about -15%; while for 6C, 30C and 200C, the percentage inhibition was 13.70%, 42.30% and 14.90%, respectively. This shows inhibitory nature for aggregation, with maximum inhibition shown by Hydrang. 30C potency. Conclusion: The homoeopathic preparations of the Hydrang. inhibit the primary events of stone formation. The findings of the above experiment show the evidence to support the usefulness of Hydrang. in the cases of renal calculi.
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REVIEW ARTICLE Top

Preclinical updates of the homoeopathic medicines used in diabetes mellitus: A narrative review p. 31
G V Narasimha Kumar, V Chitra, Pankaj Gupta, Bibaswan Biswas, Renu Arya
DOI:10.4103/ijrh.ijrh_96_19  
Introduction: Homoeopathy, one of the most commonly employed alternative medicines globally, has a wide range of role in the management of diabetes. Screening of the action of homoeopathic medicines in diabetes on animal model not only helps in validating their antidiabetic potential but also aids in understanding their effect on living systems and their mechanism of action. The present review focusses on the collection of results of pre-clinical studies carried out on homoeopathic medicines employed in the management of diabetes. Methodology: PubMed, HomBRex portal, and published literature such as library catalogue were searched up to November 2019. The search terms employed were 'Homoeopathy', 'Diabetes' and their MeSH variations in PubMed and in HomBrex search was made using the condition 'Diabetes'. Results: Fifteen studies were included in the review. Twenty medicines were evaluated for their antidiabetic efficacy either in vivo or in vitro. Most of the preclinical research on diabetes was carried out on Syzygium jambolanum and Cephalandra indica in mother tincture form and potencies, substantiating their effectiveness in the management of diabetes. Apart from the medicines discussed in the current review, there are many other medicines in Homoeopathy which are used to treat diabetes and these also should be validated scientifically for global acceptance by the scientific fraternity. Conclusion: Considering the hypoglycaemic potential, availability and cost-effectiveness of homoeopathic medicines, future research should focus on screening their effectiveness in the management of diabetic complications and other metabolic disorders.
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CASE REPORTS Top

Usefulness of individualised homoeopathic medicine in Manic episode - A case report p. 41
S Karunakara Moorthi, P Radhika, KC Muraleedharan
DOI:10.4103/ijrh.ijrh_25_20  
Introduction: Mania is a form of mood disorder initially, characterised by elevated mood, insomnia, increased libido and grandiosity. More severe forms develop elation and grandiose delusions. Case Summary: A patient reported in the Out Patient Department with symptoms of increased delusions for 3 weeks. The consultant psychiatrist diagnosed it as a case of bipolar affective disorder, current episode manic with psychotic features. Young mania rating scale (YMRS) scored 38 at the time of admission. Lachesis mutus 200 was prescribed initially and later Lycopodium clavatum 200 was prescribed, as the symptom picture changed. Overall improvement was noticed clinically and in YMRS after treatment. In this case, individualised homoeopathic treatment has shown a positive role for the remission of manic episode with psychotic features without the support adjunctive therapy or conventional medication in the current episode.
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Obliteration of ranula with homoeopathic treatment: A case report p. 48
Partha Pratim Pal
DOI:10.4103/ijrh.ijrh_27_20  
Introduction: Ranula is a soft translucent swelling that occurs in the floor of the mouth usually causing mild discomfort to the patient. Conventional therapeutic modalities range from the injection of sclerosing agents to various surgical techniques. Only a few documented cases with non-surgical management are available on literature search, as surgery is considered to be the mainstay for this clinical condition. Case Summary: This is a case of a female child with a painless, cystic swelling in the right side of the floor of the mouth of 3-month duration and another smaller painless cystic swelling on the inner side of the right lower lip. Clinical diagnosis reveals the cystic mass in the floor of the mouth as a simple ranula. After individualising the case, homoeopathic medicine Ambra grisea 30 was prescribed, and within 2–3 months, ranula obliterated. The other smaller cystic swelling also disappeared simultaneously.
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Homoeopathy for management of type 2 diabetes mellitus in a patient of major depressive disorder - A case report p. 55
Karanpreet Nahar, Subhash Kaushik
DOI:10.4103/ijrh.ijrh_12_19  
Introduction: Major depressive disorder in diabetic individuals represents a multifactorial phenomenon resulting from interactions between biological and psychosocial factors, which may intensify the probability of developing type 2 diabetes mellitus (T2DM) in otherwise healthy individuals. Case Summary: A case of T2DM is reported in a 38-year-old woman suffering from major depressive disorder who was treated successfully with individualised homoeopathic medicines. The patient reported to the Lifestyle Disorders clinic of Homoeopathic Hospital, Noida, with recently diagnosed diabetes of 8 months. After individualised homoeopathic treatment, the patient's fasting plasma glucose, postprandial glucose, HbA1c levels, fasting plasma insulin and Hamilton Depression Rating Scale score were reduced within 6 months. The findings in this case report are encouraging and provide evidence in supporting the effectiveness of individualised Homoeopathy in reducing hyperglycaemia in a patient with major depressive disorder.
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DISCUSSION Top

Active principle in potentised medicines: Nanoparticle versus quantum domain – An overview p. 62
Papiya Nandy, Durga Sankar Bhar
DOI:10.4103/ijrh.ijrh_5_20  
Background: The fact that homoeopathic medicines act even at very high dilutions has created a confusion amongst scientists. This led to different models such as formation of nanoparticles and memory of water. The basic question 'what is responsible for physiological activity of homoeopathic medicines' is yet to be answered conclusively. Objective: The objective of this overview was to find out if formation of nanoparticles or creation of quantum domain in the medium is responsible for the physiological activity of homoeopathic medicines. Methods: This overview is based on the experiments done between 2004 and 2019. Results: The succussion of the medicine has the following effects: i. At high potency, due to the mechanical energy transferred to the system, the size of the substrate reduces to nanodimension increasing membrane permeability. Furthermore, they affect several electrical properties of an electroactive polymer and enhance thermovoltage generation. ii. In the presence of an ambient electromagnetic field, domains composed of the vehicular polar molecules are formed, which bear the signature of the dissolved solute. The domains are sources of quasi-free electrons which are manifested in voltage generation separating two different polar media. The structured water also explains the ultraviolet–visible (UV-Vis) spectra. Conclusion: In high potency, formation of nanoparticles explains the effect of homoeopathic medicines on properties such as permeability, electrical properties of polymers and thermovoltage generation, whereas formation of domains in the vehicle medium explains properties such as voltage generation separating two different polar media and UV-Vis spectra.
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BOOK REVIEW Top

Evidence-based research of homoeopathy in dermatology p. 70
Divya Taneja
DOI:10.4103/ijrh.ijrh_11_21  
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RESEARCH UPDATES Top

Research highlights p. 71
Sarita Gola, Parul
DOI:10.4103/ijrh.ijrh_12_21  
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