DRUG STANDARDISATION

Year : 2009  |  Volume : 3  |  Issue : 1  |  Page : 6-17

Biochemical and Haematological Evaluation of Different Potencies of Homoeopathic Drug Ricinus Communis

EN Sundaram¹, P Uma Maheswara Reddy², KP Singh¹, K.R. Janardanan Nair³, Ch. Raveendar³, C Nayak^3
1 Drug Standardisation Unit, Hyderabad, India
² Osmania University, Hyderabad, India
³ Central Council for Research in Homoeopathy, New Delhi, India

Correspondence Address:
E N Sundaram
Research Officer (Endocrinology), Drug Standardisation Unit (H), O.U.B -32, Vikram Puri, Road No. 4. Habsiguda, Hyderabad - 500007
India

Source of Support: None, Conflict of Interest: None

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Although the seeds and / or oil of R.communis have been reported to be highly toxic, these seeds are being used in nursing women to increase the flow of milk. There is therefore a need to generate data on the biochemical and haematological profiles. Four potencies (3x, 6x, 12x and 30x) of this drug were administered orally in daily doses of 0.1 ml, 0.2 ml and 0.5 ml/rat for 14 days. The biochemical and haematological profiles of animals were studied on 21st and on 28th day during post -treatment period. Preliminary studies carried out with 4 potencies of R. communis on biochemical ( serum glucose, serum cholesterol , serum triglycerides, serum total protein, serum albumin, serum urea and serum SGOT and serum SGPT levels) and on haemotological (haemoglobin, total R.B.C. and W.B.C and differential leucocytes counts) profiles showed variable effects of different potencies of R. communis but mostly within the normal range of healthy animals. Only one rat in 12x potency group showed spear/spindle shaped R.B.C. with very less haemoglobin content. Further study is needed to confirm the effect of 12x potency on haematological profiles. The effects of R. communis significantly reduced on body weights of rat while on while no apparent difference in behaviour of animals was observed during and 14 days post-treatment.

Keywords: ricinus communis, homoeopathy, potencies, biochemical and haematological profiles, albino rats