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  Citation statistics : Table of Contents
   2016| April-June  | Volume 10 | Issue 2  
    Online since June 10, 2016

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The contribution of homeogenomic and homeogenetic studies in the support of the practice of Homoeopathy
Peter H Kay, Anisur R Khuda-Bukhsh
April-June 2016, 10(2):101-107
Almost two decades ago, it was postulated that homoeopathic remedies could deliver their benefits by interacting with the genetic blueprint. Over the years, the results of many homeogenomic gene expression studies have confirmed this postulate. The results of homeogenomic studies have begun to recognize which of the estimated 25,000 human genes are targeted by different homoeopathic remedies and how the expression profiles of these targeted genes are rearranged. From a mechanistic standpoint, seminal homeogenomic studies have shown that homoeopathic remedies can also facilitate epigenetic modifications such as DNA methylation. This is an important discovery because DNA methylation plays an important role in the control of the expression of many genes. Understanding of the genes targeted by different homoeopathic remedies, taken together with information about the function of the protein/s encoded by the targeted gene/s provides a further complementary approach to homoeopathic remedy selection. In this review, as an example, we show how the results of homeogenomic studies support the applicability of frequently used homoeopathic remedies in patients suffering from cancer, particularly with respect to upregulation of the gene TP53. This review also outlines how the results of homeogenomic studies may also provide further help with potency selection and optimum dosage regimen.
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A case of multiple urinary calculi
P Paul Sumithran
April-June 2016, 10(2):142-149
A patient with urinary calculi of sizes 16 mm in the right renal pelvis and 9 mm in the right mid-ureter, presenting with complaints of pain in right iliac region extending to genitals and legs with dribbling urine and painful micturition reported in the OPD of the Central Research Institute for Homoeopathy, Kottayam, Kerala. Patient had not undergone treatment before. Based on the presenting symptoms Nux vomica 30C was prescribed, which proved to be effective in the dissolution and expulsion of both the stones.
  1 10,142 586
Homoeopathic management of Schizophrenia: A prospective, non-comparative, open-label observational study
Praveen Oberai, S Gopinadhan, Anita Sharma, Chaturbhuja Nayak, Kalpana Gautam
April-June 2016, 10(2):108-118
Objectives: To evaluate the usefulness of homoeopathic intervention in Schizophrenia, in untreated cases and antipsychotic treatment resistant cases, to verify indications of medicines, and to assess relapse, if any. Materials and Methods: A prospective, non-comparative, open-label observational study was carried out from October 2005-September 2010 by CCRH at Central Research Institute (H), Kottayam, Kerala, India. Patients between 20 and 60 years of age, presenting with symptoms of Schizophrenia were screened for inclusion and exclusion criteria. The patients who were on antipsychotic drugs were allowed to continue the same along with homoeopathic medicine, the dose of antipsychotics was monitored by the Psychiatrist. The symptoms of each patient were repertorized, and medicine was initially prescribed in 30C potency after consulting Materia Medica. Patients were followed up for 12 months. Outcome of treatment was assessed with Brief Psychiatric Rating Scales (BPRS). Analysis was done using Statistical Package for the Social Sciences  SPSS Version 20.0. Results: Out of 188 enrolled patients, 17 cases did not complete the baseline information. Total 171 patients were analysed as per modified Intention to Treat Principle. Significant difference (P = 0.0001, P < 0.05) in the mean scores of BPRS, using paired t test was observed at end of the study. Sulphur, Lycopodium, Natrum muriaticum, Pulsatilla and Phosphorus were found to be the most useful medicines in treating schizophrenic patients. Conclusion: The study reflects the positive role of homoeopathic medicines in the management of patients suffering from schizophrenia as measured by BPRS.
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Book review on Homoeopathic Materia Medica of Sarcodes
Farokh J Master
April-June 2016, 10(2):161-161
  - 2,010 361
Key areas of homoeopathic research
Raj K Manchanda
April-June 2016, 10(2):97-100
  - 2,489 578
Pharmacognostic and physicochemical standardization of homoeopathic drug: Rumex crispus L.
Subramanian Palani, Padma Rao Pogaku, Sudhakar Penthala, PS Narayana
April-June 2016, 10(2):119-125
Background: Rumex crispus L., commonly called as "yellow dock" in English, "patience frisee" in French, and "Ampfer" in German, and 'aceda de culebra' in Spanish is a well-known herb belonging to Polygonaceae. Roots of the herb are used as medicine in homoeopathy. Objective: The pharmacognostic and physicochemical studies on roots have been carried out to enable the use of correct species and standardize the raw material. Materials and Methods: Pharmacognostic studies on roots of authentic raw drug have been carried out; physicochemical parameters, namely, extractive value, ash values, formulation besides weight per mL, total solids, alcohol content along with high-performance thin layer chromatography (HPTLC) and ultraviolet studies for mother tincture have been worked out. Results: Roots are blackish-brown, wiry, rounded with irregular striations, tortuous; internally, it is softwood, light-yellow, and fracture fibrous. Phellem is 8-10 layered, discontinuous, and tanniniferous. Phellogen is two-layered and contains inulin crystals in few. Outer phelloderm is 12-16 layered often containing spherocrystals and associated with stone cells. Secondary phloem is up to 25 layered. Xylem is in the form of strips. The physicochemical properties and HPTLC values of the drug are standardized and presented. Conclusion: The powder microscopic features and organoleptic characters along with anatomical and physicochemical studies are diagnostic to establish standards for the drug.
  - 2,384 395
Standardization of the potentizing machine and quantification of impact of potentization
Rajesh Shah
April-June 2016, 10(2):126-132
Introduction: Lack of accuracy and uniformity of impact have been the limitations of the ancient and current methods of potentization. Non-standardized electromechanical potentizers are in use across industry. It is very important that within each manufacturing process, the number of succussions should remain constant as well as the impact given (force exerted) is quantified. The author proposes to give importance to the force parameters in potentization and quantify the impact of potentization. Materials and Methods: The author develops electromechanical potentizer with certain specifications such as arm length, weight, and angle at which the arm drops at the base. The machine was operated with specific instructions given in the machine operation manual. The force parameters were calculated and standardized. Results: Torque is measured to quantify the impact of the force applied in potentization. The magnitude of torque is to be calculated by the force applied, length of the lever arm connecting the axis to the point of force application, and angle between the force vector and the lever arm. In this case, torque was calculated to be = 40.43 Nm. Since ten strokes are given, torque applied at every potency is calculated as 40.43. Conclusion: Necessity for the documentation of force parameters used in the process of potentization has been identified, and a tool is developed to demonstrate it.
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Anxiety and its impact on quality of life among urban elderly population in India: An exploratory study
Kathika Chattopadhyay, Anand Pratap Singh
April-June 2016, 10(2):133-141
Background: Persistent suffering in anxiety can cause various health problems in old age and impairment of quality of life (QOL). Objectives: The objectives of this study are to assess the pattern of covert and overt anxiety among elderly population, to study the nature of relationship between the pattern of anxiety and domains of World Health Organization-QOL (WHO-QOL) among elderly population, to study the gender difference on the pattern of anxiety and WHO-QOL among elderly population. Materials and Methods: An exploratory cross-sectional survey under a health camp approach was conducted by using two types of questionnaire, i.e., Institute for Personality and Ability Testing self-analysis questionnaire and WHOQOL-BREF. Results: The gender wise comparative profile of covert and overt anxiety with total, standard, and sten score shows that covert anxiety is higher in male in different background characteristics, except male group educated between 5 th and 12 th standard showing higher overt anxiety, whereas female group shows higher overt anxiety in different background characteristics. Spearman's rank correlation shows that overt anxiety has an inverse relation with domain-1 in both sexes, a negative relationship is found between domain-2 of WHO-QOL and the covert and overt anxiety among female, a significant negative relationship in domain-3 of WHO-QOL with covert and overt anxiety among male, and also a significant negative association between the domain-4 of WHO-QOL and overt anxiety in female. Conclusion: The functional ability of both male and female elderly on various domains is related and influenced by the pattern of anxiety.
  - 2,347 480
Reminiscence - memory and road behind: Review of the Central Council for Research in Homoeopathy Quarterly Bulletin 1996 (volume 18) and 1997 (volume 19)
Roja Varanasi
April-June 2016, 10(2):150-152
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Research highlights: (April-June 2016)
Deepti Singh Chalia
April-June 2016, 10(2):153-160
  - 1,716 265