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   2015| January-March  | Volume 9 | Issue 1  
    Online since March 31, 2015

 
 
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ORIGINAL ARTICLES
Role of homoeopathic mother tinctures in rheumatoid arthritis: An experimental study
Surender Singh, Ritu Karwasra, Prerna Kalra, Rohit Kumar, Shalu Rani, Debadatta Nayak, YK Gupta
January-March 2015, 9(1):42-48
DOI:10.4103/0974-7168.154348  
Objectives: The objective of present preliminary study was to assess the anti-inflammatory, analgesic and anti-arthritic effect of some homoeopathic mother tinctures viz. Ricinus communis (RCMT), Rauwolfia serpentina (RSMT), Bellis perennis (BPMT), Curcuma longa (CLMT), Terminalia arjuna (TAMT) and Tribulus terresteris (TTMT). Materials and Methods: Paw oedema was induced by administration of 0.1ml 1% carrageenan in normal saline into right hind paw. Degree of inflammation was evaluated according to paw swelling. Arthritis was induced by Complete Freund's Adjuvant (CFA) injection in metatarsal footpad of Wistar albino rats. Result: Curcuma longa and Tribulus terresteris mother tinctures reduced hind paw swelling decreased the paw volume in Carrageenan treated rats. Thus, revealed potent activity against inflammation. All homoeopathic mother tinctures showed peripheral analgesic activities in hot plate induced thermal algesia in mice.
  27,941 1,527 2
RESEARCH PROTOCOL
Homoeopathic Drug Proving: Randomised double-blind placebo-controlled trial
Central Council for Research in Homoeopathy
January-March 2015, 9(1):3-11
DOI:10.4103/0974-7168.154341  
Background: The methodology of Drug Proving has evolved considerably since the times of Dr. Hahnemann. Standardisation of a proving process and quality of proving studies has been a major consideration for research over the years. Proving guidelines have been developed by various international bodies such as Homoeopathic Pharmacopoeia Committee of United States (HPCUS), European Commission of Homoeopathy (ECH) and Liga Medicorum Homoeopathica Internationalis (LMHI). Drug proving has been a major research activity of the Central Council for Research in Homoeopathy (CCRH). CCRH had over the years devised its own methodology for drug proving. A protocol for the drug proving program of the Council has been developed by harmonising the CCRH methodology with that detailed in internationally developed guidelines. Methodology: This is a generic protocol, which will be applicable for drugs being proved by the Council. These will be multi-centric, prospective, parallel arm, randomised, double-blind, placebo-controlled studies. It is recommended to have at least 30 provers who can complete the total duration of proving. The Investigational Proving Substance (IPS) will be proved in two potencies. Inter- Prover and Intra- Prover placebo control will be maintained. Proving symptoms generated will be analysed on pre-defined criteria, and characteristic symptoms of the IPS will be identified. Discussion: The protocol aims at combining the possible methods to increase the quality and to minimize bias in the study, at the same time ensuring that the IPS is proved sufficiently to evolve a pathogenesis which can then further be subjected for appropriate clinical response in patients. The protocol is open for discussion and readers are invited to send their comments and reviews on the protocol.
  9,959 865 -
CASE REPORT
An evidence-based case of acoustic/vestibular schwannoma
Girish Gupta, Naveen Gupta, Dileep Pandey
January-March 2015, 9(1):49-54
DOI:10.4103/0974-7168.154349  
A vestibular schwannoma, often called an acoustic neuroma/schwannoma, is a benign primary intracranial tumor of the myelin-forming cells of the vestibulo-cochlear nerve (8 th cranial nerve). This tumor arises from the Schwann cells responsible for the myelin sheath that helps keep peripheral nerves insulated. [1] Approximately, 3000 cases are diagnosed each year in the United States with a prevalence of about 1 in 100,000 worldwide. It comprises 5-10% of all intracranial neoplasms in adults. Incidence peaks in the fifth and sixth decades and both sexes are affected equally. Studies in Denmark published in 2004 show the incidence of 17.4/million. Most acoustic neuromas are diagnosed in patients between the ages of 30 and 60, and men and women appear to be affected equally. [2] The case illustrated here is a rare one of acoustic/vestibular schwannoma a surgical conditions, treated with Lycopodium, which produced improvement on both subjective and objective parameters.
  9,840 574 -
ORIGINAL ARTICLES
Clinical trial for evaluation of a Human Immunodeficiency Virus nosode in the treatment for Human Immunodeficiency Virus-Infected individuals
Rajesh Shah
January-March 2015, 9(1):25-33
DOI:10.4103/0974-7168.154345  
Introduction: Identifying the need for strengthening of the immune system, the investigator has developed new Human Immunodeficiency Virus (HIV) nosode and evaluated its effect on HIV positive individuals through a clinical trial. Methods: Standardized and the scientific method of HIV nosode preparation has been described and documented. Thirty-seven HIV-infected persons were registered for the trial, and ten participants were dropped out from the study, so the effect of HIV nosode 30C and 50C, was concluded on 27 participants under the trial. Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the viral load from 12 to 24 weeks. Similarly 9 participants (33.33%) showed an increase in the CD4+ count by 20% altogether in 12 th and 24 th week. Significant weight gain was observed at week 12 (P = 0.0206). 63% and 55% showed an overall increase in either appetite or weight. The viral load increased from baseline to 24 week through 12 week in which the increase was not statistically significant (P > 0.05). 52% (14 of 27) participants have shown either stability or improvement in CD4% at the end of 24 weeks, of which 37% participants have shown improvement (1.54-48.35%) in CD4+ count and 15% had stable CD4+ percentage count until week 24 week. 16 out of 27 participants had a decrease (1.8-46.43%) in CD8 count. None of the adverse events led to discontinuation of study. Conclusion: The study results revealed improvement in immunological parameters, treatment satisfaction, reported by an increase in weight, relief in symptoms, and an improvement in health status, which opens up possibilities for future studies.
  7,149 852 1
Evaluation of homoeopathic medicines as add-on to institutional management protocol in Acute Encephalitis Syndrome: An exploratory observational comparative study
Raj K Manchanda, Praveen Oberai, Varanasi Roja, Supriya Singh, Neha Singh, Tariq Khan, Ramesh Prasad, JR Singh
January-March 2015, 9(1):34-41
DOI:10.4103/0974-7168.154347  
Background: Acute Encephalitis Syndrome (AES) treated according to Institutional Management Protocol (IMP) has considerable mortality and morbidity. The study was undertaken to evaluate the effect of homoeopathic treatment (H) as an add-on to IMP (IMP + H) for children affected with AES. Materials and Methods: This was an exploratory observational study carried out in the IPD setting (epidemic ward) of Baba Rhaghav Das Medical College and Nehru Hospital, Uttar Pradesh (July to November 2012) using convenience sampling. Children whose guardians gave consent were treated with IMP + H and rest remained on IMP only. Glasgow outcome scale was used at discharge for the final outcome. Results: 151 children (121 in IMP + H and 30 in only IMP) diagnosed with AES (aged 6 months to 18 years) were enrolled. The results showed 12 (9.9%) death out of 121 children administered IMP + H whereas it was 13 (43%) out of 30 children on IMP alone. Proportional odds analysis with covariate adjustment showed added benefit of Homoeopathy in children with AES as compared to IMP alone (adjusted odds ratio, 0.17, 95% confidence interval 0·06-0.45, P = 0·0001). The most useful medicines are Belladonna, Stramonium, Arsenicum album, Helleborus, Bryonia alba, Sulphur, and Cuprum metallicum. Conclusion: This exploratory observational study suggests reduction of mortality and morbidity with add-on homoeopathic medicine. Further randomized controlled trial study with comparable groups is desirable. If findings are confirmed by subsequent research, add-on Homoeopathy might have relevant implication for its management.
  4,329 546 -
An investigation to evaluate the analgesic and central nervous system depressant activities of Solanum nigrum (Linn.) in Homoeopathic potencies in experimental animal models
Echur Natarajan Sundaram, Kushal Pal Singh, Pratap Karnati Reddy, Kainikkara Raven Janardanan Nair, Anil Khurana, Hari Singh, Chaturbhuja Nayak
January-March 2015, 9(1):12-19
DOI:10.4103/0974-7168.154343  
Background and Objective: In Homoeopathy, Solanum nigrum is clinically used in the treatment of ergotism, meningitis, irritation during dentition and some of the symptoms of neurological disorders but its Central Nervous System (CNS) potential has not been explored experimentally yet. Therefore, a preliminary study was conducted with an objective to evaluate the analgesic and CNS depressant effects of homoeopathic potencies of S. nigrum in experimental animal models. Materials and Methods: The study was conducted in Wistar albino rats using a hot plate, ice plate and Randall-Selitto assay for analgesic; rota-rod and open field test for CNS depressant activities. The different potencies (3X, 6X, 12X and 30C) of Solanum nigrum were administered orally (0.5 ml/rat/day) for 30 days and response was assessed after 30 minutes of drug administration on 10 th , 20 th and 30 th day. Results: The result shows that all the four potencies of Solanum nigrum has increased the latency time required to raise and lick the paws for thermal sensation on hot plate test and for cold sensation on ice plate test and also increased the degree of threshold pressure to mechanically induced pain on Randall-Selitto assay but depressed the motor coordination and locomotor activities. Conclusion: The result obtained from this preliminary study suggests that homoeopathic preparation of Solanum nigrum in different potencies possess analgesic and CNS depressant activities. Further detailed investigations are required for its possible human use.
  3,876 556 -
RESEARCH HIGHLIGHTS
Research highlights: Latest homoeopathic research synopsis during October - December 2014
Subhranil Saha, Munmun Koley
January-March 2015, 9(1):59-65
DOI:10.4103/0974-7168.154352  
  3,975 414 -
ORIGINAL ARTICLES
Pharmacognostic study of Chamaecyparis lawsoniana (Murr.) Parl.: A drug used in Homoeopathy
Anshu Rathi, D Suresh Baburaj, EN Sundaram, Sunil Kumar, Anil Khurana, Raj K Manchanda
January-March 2015, 9(1):20-24
DOI:10.4103/0974-7168.154344  
The pharmacognostic profile of crude drug has a key role in standardization for quality, purity and drug identification. The present study deals with pharmacognostic evaluation of aerial part of Chamaecyparis lawsoniana (Murr.) Parl. a drug used in homoeopathic system of medicine for diverse clinical uses such as terrible pain in stomach, tumors, keloid, warts and lipoma of thigh. The study includes collection, identification, macroscopy, microscopy and organoleptic characteristics of aerial part of Chamaecyparis lawsoniana. Anatomically the leaf is distinguishable into a layer of the epidermis followed by parenchymatous mesophyll and resin duct in the parenchymatous cortex. Powder microscopy shows the presence of epidermal cells, parenchymatous cells and tracheids. These observations may be used as pharmacopoeial standards for identification of Cha maecyparis lawsoniana.
  3,698 459 -
EDITORIAL
Editorial
Raj K Manchanda
January-March 2015, 9(1):1-2
DOI:10.4103/0974-7168.154339  
  3,029 319 -
REMINISCENCES
Old text revisited: CCRH Quarterly Bulletin, Volume 13 (1-4) 1991
Suniti Chugh
January-March 2015, 9(1):55-58
DOI:10.4103/0974-7168.154350  
  2,816 253 -
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