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   2014| January-March  | Volume 8 | Issue 1  
    Online since March 29, 2014

 
 
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ORIGINAL ARTICLES
To evaluate the role of homoeopathic medicines as add-on therapy in patients with rheumatoid arthritis on NSAIDs: A retrospective study
Tapas K Kundu, Afroz F Shaikh, Sindhu M Jacob
January-March 2014, 8(1):24-30
DOI:10.4103/0974-7168.129674  
Background: Conventional management of Rhematiod Arthritis (RA) includes administration of Non- Steroidal Anti- Inflammatory Drugs (NSAIDs), disease modifying anti-rheumatic drugs (DMARDs) like Methotrixate and anti-tumor necrosis factor α monoclonal antibody (anti-TNFά). Gastric ulcers, bleeding and perforation are the most common known adverse reactions found associated with excessive consumption of NSAIDs. The homoeopathic system of medicine improves the general well being, that is, Quality of Life (QoL) in addition to reducing the pain and disability. Objective: To evaluate the patients with RA receiving homoeopathic medicines with respect to QoL, Disease Activity Score (DAS), Erythrocyte Sedimentation Rate (ESR), morning stiffness/pain and frequency of analgesics after homoeopathic intervention. Design: This is a retrospective analysis of the role of homoeopathic medicines in RA. Patients diagnosed as sero-positive for RA antigen receiving homeopathic medicines were analysed for DAS, QoL, frequency of analgesics, ESR and pain/morning stiffness. Materials and Methods: Ten cases testing sero-positive for RA with at least four clinical signs were evaluated from single homoeopathic Out-Patient Department (OPD) from February 2009 and February 2011. Cases were analysed to find out the role of homoeopathic constitutional similimum in people with RA. Changes in DAS, ESR, pain/morning stiffness and QoL were considered as outcome measure. Results: Homoeopathic constitutional medicines were found to reduce the intensity of pain in patients with RA (t = 4.3733, P < 0.01) along with reduction in consumption of NSAIDs (t = 2.4, P < 0.05). The DAS reduced in all 10 patients (t = 2.67, P < 0.01). The QoL was also found to improve under homoeopathic medication (t = 4.044, P < 0.01) and no further deterioration joint/disability was observed in any of the 10 patients. Mean ESR improved to 19.5 from 38.1 (t = 2.235, P < 0.05). Out of 10, 3 (30%) patients were found to be sero-negative after homoeopathic constitutional similimum. Conclusion: Homoeopathic constitutional similimum improves the QoL of patients with RA by reducing intensity of pain, limiting disability and reducing disease activity, thus causing improvement in general and disease condition in particular. It also limits the need of analgesics and DMARDs in RA.
  73,864 8,617 2
Dose-dependent effect of homoeopathic drug Zinc sulphate on plant growth using Bacopa monnieri as model system
Vivek Kumar Gupta, Jutika Rani Ray, Vishal Kumar Singh, Surya Deo Pathak, Chaturbhuja Nayak, Mahendra P Darokar
January-March 2014, 8(1):19-23
DOI:10.4103/0974-7168.129673  
Background: Zinc is one of the essential micronutrients in plants required in very low quantity for plant growth and development. In higher concentration, it is known to to reduce the rate of photosynthesis, So homoeopathic preparations tested to see it role on plan growth. Objective: To analyse the effect of homoeopathic preparation of Zinc sulphate on plants through in-vitro assay using Bacopa monnieri as a model plant system. Materials and Methods: Six homoeopathic potencies (1X to 6X) of Zinc sulphate were used on a decimal scale along with the control (MS basal agar medium). The samples were evaluated by adding fixed amount (100 μl) in the media as well as by dipping the explants in the test sample overnight. At the completion of the incubation period (14 days) the fresh and dry weight, number and length of the roots, number and length of the shoots and the number of leaves were analysed. Results: It was observed that Zinc sulphate showed growth inhibition at potencies from 1X to 5X, whereas at potency 6X, it exhibited growth promotion effect, when compared with the control. Conclusion: Homoeopathic drug (Zinc sulphate) exhibited growth promotion at higher potency (6X) and growth inhibition at lower potencies (1X to 5X) on Bacopa monneiri.
  11,761 629 -
CLINICAL PAPERS
A case of haemorrhoids in a 12-year-old boy
Padmalaya Rath, Harleen Kaur
January-March 2014, 8(1):37-41
DOI:10.4103/0974-7168.129677  
Haemorrhoids is a very common condition that a physician would encounter in day to day practice. However, haemorrhoids in children is not as common. The only known treatment for the condition in conventional medicine is surgical excision, which is generally not favoured at this age. The case reported here is that of an internal haemorrhoids in a 12-year-old child, who was treated successfully with homoeopathic medicine. The patient has been observed for more than 2 years without recurrence. Photographs were taken before and after treatment to record changes in the condition. Non-recurrence of complaint in the past two and half years suggests that a 'near permanent' cure is achievable through individualised homoeopathic treatment.
  10,047 730 -
Usefulness of classical homoeopathy for the prevention of urinary tract infections in patients with neurogenic bladder dysfunction: A case series
Jürgen Pannek, Susanne Pannek-Rademacher, Martine Cachin Jus, Mohinder Singh Jus
January-March 2014, 8(1):31-36
DOI:10.4103/0974-7168.129675  
Context: In patients with neurogenic lower urinary tract dysfunction due to Spinal Cord Injury (SCI), recurrent Urinary Tract Infections (UTI), is a frequently encountered clinical problem. Often, conventional preventive measures are not successful. Aims: To treat the patients of SCI suffering from recurrent UTI with classical homoeopathy as add-on to standard urologic care. Materials and Methods: After exclusion of morphological abnormalities and initiation of a standard regime for prophylaxis, all patients with a neurogenic lower urinary tract dysfunction due to SCI, with more than three symptomatic UTI/year, were offered additional homoeopathic care. Symptoms were fever, incontinence, increased spasticity, decreased bladder capacity or pain/decreased general health combined with significant bacteriuria. Descriptive statistics was used for analysis. Results: Eight patients were followed up for a median period of 15 months. Five patients remained free of UTI, whereas UTI frequency was reduced in three patients. Conclusion: Our initial experience with homoeopathic prevention of UTI as add on to standard urologic prophylactic measures is encouraging. For an evidence-based evaluation of this concept, prospective studies are required. Keys for the positive outcome of this case series are co-operation of well-qualified partners, mutual respect and the motivation to co-operate closely.
  8,030 757 4
RESEARCH PROTOCOL
Homoeopathy in polycystic ovarian syndrome: A randomized placebo-controlled pilot study
Central Council for Research in Homoeopathy
January-March 2014, 8(1):3-8
DOI:10.4103/0974-7168.129671  
Background: Polycystic ovarian syndrome (PCOS) is an emerging health problem in young females characterized by ovarian dysfunction and hyperandrogenism. Existing information indicates a positive role of homoeopathy but more rigorous studies are desirable. This protocol has been developed to undertake a pilot study to evaluate the efficacy of homoeopathic intervention using established diagnostic criteria. Methods/Design: It will be a multi-centric, randomized, placebo controlled pilot study with a 6-month intervention and follow up period. Minimum 60 cases fulfilling the eligibility criteria will be enrolled and randomized to receive either the homoeopathic intervention or the identical placebo. Both the arms follow lifestyle modification for weight reduction. Primary endpoint will be the establishment of regular menstrual cycle along with improvement in either ultrasonology or hirsutism/acne. Secondary endpoints will be to compare the changes in total and individual domain scores of PCOS questionnaire at monthly interval and the changes in ultrasound of polycystic ovaries. For the primary outcome and each of the secondary outcomes, both per protocol and modified intention to treat analysis will be done. Discussion: This pilot study has been planned considering the varied presentation of PCOS as per international diagnostic criteria and accordingly the composite endpoints have been kept for evaluation. The outcome of this pilot study will help in planning a definite study. Trial registration: CTRI/2013/09/003983 [Registered on: 16/09/2013].
  5,634 1,404 2
ORIGINAL ARTICLES
A multi-centric double blind homoeopathic pathogenetic trial of Hygrophila spinosa
G Rakshit, AK Vichitra, PK Chandra, Rajpal , Vinay Kr. Singh, SK Choudhury
January-March 2014, 8(1):9-18
DOI:10.4103/0974-7168.129672  
Objective: The study was conducted to elicit the pathogenetic response of Hygrophila spinosa in homoeopathic potencies on healthy human volunteers. Methodology: The drug Hygrophila spinosa was proved by the Central Council for Research in Homoeopathy (CCRH) through randomized, double-blind, placebo-controlled method. The proving was conducted at three centres viz. Central Research Institute (H), [CRI (H)] Noida, Drug Proving Unit [DPU], Bhubaneswar and Regional Research Institute (H) [RRI (H)], Kolkata. The drug was proved in two potencies (6C and 30C) on 48 apparently healthy volunteers who were selected after conducting pre-trial medical examinations by the medical specialists and routine laboratory investigations. 32 of them where kept on interventional drug trial and remaining took placebo. At CRI (H), NOIDA, 56 dose schedule (i.e. 56 doses of drug/placebo were consumed in each batch) was followed while at DPU, Bhubaneswar and at RRI (H), Kolkata, 12 dose schedule (i.e. 12 doses of drug/placebo were to be consumed in each batch) was followed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the Proving Masters which were compiled at Homoeopathic Drug Proving-cum-Data Processing cell of CCRH headquarters after decoding. Results: Out of 32 provers who were on interventional drug trial, only 14 manifested symptoms. The drug was able to produce symptoms in both the potencies. 92 symptoms appeared during the drug trial from various locations. Conclusion: The drug pathogenesis evolved indicates its therapeutic use for urticaria, frontal sinusitis, conjunctivitis, stomatitis, gastroenteritis, nausea (morning sickness), intermittent fever etc.
  5,131 545 1
BOOK REVIEW
Lymphatic Filariasis:Homoeopathic approach
Rajat Chattopadhyay
January-March 2014, 8(1):45-45
DOI:10.4103/0974-7168.129679  
  3,941 448 -
REMINISCENCES
CCRH quarterly bulletin, Volume 9 (1-4), 1987
Nirupama Mishra
January-March 2014, 8(1):42-44
DOI:10.4103/0974-7168.129678  
  2,239 395 -
RESEARCH HIGHLIGHTS
Research Highlights
Ritika Hassija Narula, Subhranil Saha, Munmun Koley
January-March 2014, 8(1):67-69
DOI:10.4103/0974-7168.129681  
  2,024 300 -
CONFERENCE REPORT
Proceedings of interactive meet on harmonisation of drug proving programme
Raj K. Manchanda, Anil Khurana, Divya Taneja
January-March 2014, 8(1):46-66
DOI:10.4103/0974-7168.129680  
An interactive meet for harmonisation of drug proving programme of the CCRH was held on 17 September 2013 with an objective to exchange information on standards and methods of proving in the USA, Europe and India and promote international collaboration and harmonisation of drug proving protocol. The Council is in the process of revising its drug proving protocol based on the deliberations of the meet.
  1,818 264 1
EDITORIAL
Editorial
Raj K. Manchanda
January-March 2014, 8(1):1-2
DOI:10.4103/0974-7168.129668  
  1,651 343 -
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