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  Citation statistics : Table of Contents
   2013| January-March  | Volume 7 | Issue 1  
    Online since June 29, 2013

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A multi-centric double-blind randomized homoeopathic pathogenetic trial of Gymnema sylvestre
Goutam Rakshit, JP Singh, SD Pathak, Ch Kishan Banoth, PK Chandra, Rajpal , Sujata Kumari Choudhury, Vinay Kr Singh
January-March 2013, 7(1):9-21
Objective: To elicit the pathogenetic response of Gymnema sylvestre in homoeopathic potencies on apparently healthy human volunteers. Methodology: Gymnema sylvestre was proved by the Central Council for Research in Homoeopathy through double-blind placebo-controlled method. The study was carried out at four centers. The drug was proved in two potencies (6C and 30C) on 63 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses (04 doses per day for 14 days) of each potency or placebo were consumed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the proving masters. The data obtained from all the four centers was compiled at proving-cum-data processing cell at CCRH headquarters after decoding. Results: Out of 37 provers who were on actual drug trial, 16 manifested symptoms. The drug was able to produce symptoms in each potency in most of the parts of the body. Conclusion: The pathogenetic responses elicited during the drug proving trial expand the scope of use of the drug Gymnema sylvestre and will benefit the research scholars and clinicians. The generated symptoms of the drug will carry more meaning when verified clinically.
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Keynotes of homoeopathic materia medica Volume-1
SR Sharma
January-March 2013, 7(1):33-33
  - 3,327 617
Homoeopathy in influenza like illness
RK Manchanda
January-March 2013, 7(1):1-2
  - 4,047 662
Effect of individualized homoeopathic treatment in influenza like illness: A multicenter, single blind, randomized, placebo controlled study
PS Chakraborty, CD Lamba, D Nayak, MD John, DB Sarkar, Amitava Poddar, JS Arya, K Raju, Kumar Vivekanand, H Binod Kumar Singh, H Baig, AK Prusty, Vikram Singh, C Nayak
January-March 2013, 7(1):22-30
Background: In the past decade the upsurge of influenza throughout the globe was significant and in recent years this has resurfaced showing failures of all the preventive and therapeutic measures against it. Thus, this study was undertaken to evaluate the effect of homoeopathic medicines in the treatment of Influenza like illness (primary objective) and to compare the complication rate among patients receiving homoeopathic medication as compared to the patients receiving placebo and also to compare the efficacy of LM potency vis-ΰ-vis Centesimal potency (secondary objective). Material and Methods: This was a multicenter, prospective, randomized, triple arm placebo controlled trial conducted at nine Institutes and Units of Central Council for Research in Homoeopathy (CCRH) from June 2009 to December 2010. The patients fulfilling the inclusion criteria were randomized to LM, Centesimal and Placebo groups. Homoeopathic interventions were given as per the principles of homoeopathy. Symptoms of Influenza like illness (ILI) were assessed as per validated scales. Data analysis was done using statistical package of SPSS 20.0 version. Each symptom was compared for 10 days among the allocated groups by using Kruskal wallis test and bonferroni correction for the multiple comparisons. Results: Out of 739 screened cases, 447 cases were eligible for enrolment comprising of LM (n=152), (n=147) and placebo (n=148) cases. There was a significant difference in temperature from 2 nd day onwards in LM and Centesimal groups. The significant improvement was observed in headache and myalgia on 1 st day in both the treatment groups. Likewise, significant improvement was noted in malaise on 2 nd day in both the groups; sore throat on 1 st day in LM and 2 nd day in Centesimal; fatigue on 2 nd day in LM and on 3 rd day in Centesimal group; nasal complaints on 2 nd day in LM and 1 st day in Centesimal group; chill on 3 rd day in LM group and 1 st day in Centesimal group and in sweat on 1 st day in the treatment groups. Cough improved significantly from 3 rd day in both the groups. Conclusion: The study revealed the significant effect of individualized homoeopathic treatment in the patients suffering from ILI with no significant difference between LM and Centesimal groups. The complication/sequel rate was also significantly less in the intervention groups.
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Pharmacognostic and high performance thin layer chromatography finger printing of Pyrus malus Linn
P Padma Rao, P Subramanian, P Sudhakar, T Sheshashena Reddy, P Ramachandra Reddy, D Suresh Baburaj
January-March 2013, 7(1):3-8
Background: Pyrus malus L. Syn. Malus sylvestris Mill., commonly known as 'Apple' is a well known tree belonging to the family Rosaceae. Leaves and young aerial parts are used as medicine in homoeopathy. Objective: The Pharmacognostic and physico-chemical studies are carried out to facilitate use of correct species and standard raw materials. Material and Methods: Pharmacognostic examinations of aerial parts (leaf, petiole and stem) of authentic sample of Pyrus malus L., have been carried out. Physico-chemical parameters of raw drug viz., extractive value, ash values, formulation besides weight per mL, total solids, alcohol content along with high performance thin layer chromatography (HPTLC) and UV-visible studies have been worked out for mother tincture. Results: The leaves are ovate to oblong, margin serrate, acute, glabrous above and tomentose beneath with a short petiole. The leaf is hypostomatic with anomocytic stomata. Uniseriate macroform flagellate conical and unicellular filiform cylindrical hairs occur on the leaf. In transverse section (TS) the midvein is conspicuously ridged on abaxial side. Epidermis is 1-layered with larger cells on abaxial. Cells over midvein are papillated. Palisade is 2-layered. The vascular bundle at midvein is single, large and arc shaped. The petiole in T.S. is shield like with an adaxial groove. The cortex is aerenchymatous towards adaxial. The vascular tissue consists of a single, large, arcuate bundle and two small adaxial bundles. The young stem is oval to spherical. The vascular tissue is in the form of a continuous cylinder. 1-3 seriate rays are present in the xylem. The xylem towards the centre possess secretory canals arranged in a ring. Conclusion: The powder microscopic features and organoleptic characters along with the anatomical and physico-chemical studies are diagnostic to establish the standards for the drug.
  - 3,206 489
Review of CCRH quarterly bulletin (1983)
Kusum Chand
January-March 2013, 7(1):31-32
  - 2,552 366