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   2012| July-September  | Volume 6 | Issue 3  
    Online since December 1, 2014

 
 
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Homeopathy emerging as nanomedicine
Rajendra Prakash Upadhyay, Chaturbhuja Nayak
July-September 2012, 6(3):31-38
Background:Homeopathy is a time-tested two-century old empirical system of healing. Homeopathic medicines are prepared through a characteristic process known as potentization, where serial dilutions are performed with strong strokes at each step of dilution. Homeopathy is controversial because most medicines do not contain one single molecule of the corresponding starting-substance. Aim:To investigate a possible nanoscience mechanism of action of homeopathic medicines. Methodology: Ultra-pure samples were prepared and were examined under scanning (SEM) and transmission electron microscope (TEM) along with selected area nanodiffraction (SAD) and energy-dispersive X-ray analysis (EDX). Also trace element analysis (TEA) for silicon was performed. Results:Homeopathic medicines showed not to be „nothing", but exhibited nanoparticles and conglomerates of them, which had crystalline nature and were rich in silicon. Conclusions:During the violent strokes involved in potentization, information arising from the serially diluted starting-substance might be encrypted by epitaxy on silicon-rich crystalline nanoparticles present in the resulting homeopathic medicine. The 'size' of the information encrypted on nanoparticles might vary together with the degree of dilution. As homeopathic medicines exhibit healing effects, these nanoparticles along with the interfacial water on their surface might carry this information - which biological systems are able to identify - to the target. As various forms of silica are known to interact with proteins and cells of the immune system, homeopathy might represent a nanomedicine system. Possible confirmation, however, requires further research in materials and interfacial water.
[ABSTRACT]   Full text not available  [PDF]
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ORIGINAL ARTICLES
Homoeopathic medicines in the management of benign prostatic hyperplasia: A multicentric prospective observational study
Praveen Oberai, Varanasi Roja, D Ramesh, DD Arya, G Ravi Chandra Reddy, SK Sharma, Chaturbhuja Nayak, Vikram Singh, Hari Singh
July-September 2012, 6(3):16-25
Objectives:The primary objective of this study was to determine the therapeutic usefulness of a group of predefined trial medicines in benign prostatic hyperplasia. The secondary objective was to check the progression of disease by evaluating changes in prostate volume (PV), post-void residual urine (PVRU) and peak urine flow rates (Qmax and Qavg in ml/sec). Methods:In a multi-centric observational study, 231 patients suffering from benign prostatic hyperplasia (BPH) having prostate volume > 20 mL and prostate specific antigen (PSA) ≤ 4 ng/mL were enrolled at 5 Institutes/Units under Central Council for Research in Homeopathy (CCRH). Symptoms were analyzed using the American Urological Association Symptom Index (AUASI). Parameters like PSA, Prostate volume, Post void residual urine, Qmax, Qavg were also analyzed. Twenty pre-defined homoeopathic medicines were short-listed for prescription after repertorizing the pathological symptoms of BPH. The appearance of any change (relief/worsening)/status quo was immediately followed by placebo/ change in potency/change in remedy. The follow-up period was for one year. The analysis was done as per intention to treat principle. Statistical analysis was done using SPSS version 16. Results:The data of 187 patients out of 231 enrolled was analyzed. The non-parametric Friedman test was applied to test for significant difference in AUASI score reported over 12 months (baseline, 3 months, 6 months and 12 months). There was a statistically significant reduction in AUASI score (median change of 13 points, p= 0.0001) on completion of one year of treatment. A total of 10 out of 20 pre-defined medicines were prescribed to 187 patients. The medicines found to be most useful in this study are: Thuja (27 out of 53; 51%), Sulphur (26 out 46; 56.5%), Pulsatilla (34 out of 46; 74%), Lycopodium.(7 out of 13; 54%).There was a mean reduction of 2.3 ml in prostate volume, which was significant satistically (p=0.005). Conclusion:Homoeopathic medicines significantly improved lower urinary tract symptoms in men with BPH. Placebo-controlled trials are needed to evaluate their efficacy and effectiveness.
[ABSTRACT]   Full text not available  [PDF]
  980 326 -
CASE RECORD
An evidence based case study of benign prostatic hyperplasia
Girish Gupta, Santosh Singh
July-September 2012, 6(3):26-30
Benign prostatic hyperplasia (BPH) has been the most frequent reason for elderly men undergoing surgery. BPH symptoms range from least voiding difficulties to urinary retention and renal failure. In this case of BPH, subjective measures such as changes in International Prostatic Symptom Score / American Urological Association Assessment (IPSS/AUA), and objective measures such as changes in prostate size and urinary flow rate were assessed, as the successful management and treatment of BPH should seek both to improve symptoms and prevent disease progression. The case was treated with Lycopodium, a homoeopathic medicine reported here. This case shows the efficacy of medicine in both subjective and objective parameters without surgical intervention.
[ABSTRACT]   Full text not available  [PDF]
  939 291 -
ORIGINAL ARTICLES
A multi-centric, double-blind randomized, homoeopathic pathogenetic trial of Buxus sempervirens
Rajpal , Vinay Kr Singh, VA Siddiqui, C Nayak, AK Majumdar, PK Chandra, SK Dey, PS Sivadas
July-September 2012, 6(3):1-9
Objective:To elicit the pathogenetic response of Buxus sempervirens Linn. in homoeopathic potencies on healthy human volunteers. Methodology: Buxus sempervirens drug was proved by the Central Council for Research in Homoeopathy (CCRH) through randomized, double-blind, placebo-controlled method. The proving was conducted at three centres during 2007-08. The drug was proved in 6 & 30 centesimal potencies on 57 apparently healthy volunteers, declared eligible after their pre-trial medical examination by the medical specialists and routine laboratory investigations. In its first phase of proving, volunteers were given 56 doses of placebo divided in 4 doses per day for 14 days. In the next two phases, 56 doses of pre-selected potencies or placebo as per the randomization were consumed in divided doses same as in first phase. The symptoms generated during the trial period were noted down by the volunteers and elaborated by the Proving Masters. The generated data of the drug from all three centres was compiled at the proving-cum-data processing cell at CCRH headquarters after de-coding. Observations:Out of 40 provers who were on actual drug trial, only 23 manifested symptoms. The drug was able to generate symptoms in both the potencies to every part of the body. Conclusion: The pathogenetic response elicited during the proving trial, expands the scope of use of the drug Buxus sempervirens and will benefit the research scholars and clinicians. The generated symptoms of this drug will carry more value when verified clinically.
[ABSTRACT]   Full text not available  [PDF]
  996 168 -
Standardisation and quality control of homoeopathic drug Pimenta officinalis lindl
P Padma Rao, P Subramanian, P Sudhakar, T Sheshashena Reddy, PR Reddy, HC Gupta
July-September 2012, 6(3):10-15
Pimenta officinalis Lindl., a bushy tree commonly known as 'all spice' belongs to the family Myrtaceae. It is a potential drug in homoeopathy used in neuralgias and disturbed sensations of heat and cold. The dried unripe fruits are used as medicine. The fruit is a small pea-sized berry, blackish to reddish brown. The epicarp is conspicuous with numerous large glandular secretory cavities. The pericarp is about 2 mm thick. The mesocarpic cells contain resin, tannins and sphaerocrystals. Stone cells are also present in mesocarp. The outermost layer of seed consists of closely packed testa with attached stone cells. The endosperm consists of cells containing starch grains. The powder microscopical and organoleptic characters of powder are presented. Physico-chemical parameters of raw drug viz., extractive values, ash values, formulation and standardisation of mother tincture like wt. per ml, total solids, alcohol content, pH along with HPTLC and UV studies have been undertaken.
[ABSTRACT]   Full text not available  [PDF]
  772 163 -
BOOK REVIEW
Disease Monograph — Urolithiasis
Seema Rai
July-September 2012, 6(3):45-45
Full text not available  [PDF]
  443 170 -
EDITORIAL
Editorial
RK Manchanda
July-September 2012, 6(3):0-0
Full text not available  [PDF]
  443 156 -
REMINISCENCES
CCRH Quarterly Bulletin (1979-81)
VP Singh
July-September 2012, 6(3):39-44
Full text not available  [PDF]
  456 120 -
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