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   2011| April-June  | Volume 5 | Issue 2  
    Online since December 2, 2014

 
 
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CASE RECORD
A case of colloidal nodular goiter
Bindu Sharma
April-June 2011, 5(2):40-46
Most thyroid nodules are asymptomatic. Visible nodules are of great concern to the patient because of the cosmetic embarrassment they cause. Affected patients are euthyroid i.e. serum T3, T4 & TSH are normal. A case of colloidal nodular goiter presented at Regional Research Institute (RRI) (H), Shimla. Her thyroid profile was within normal range and Fine Needle Aspiration Cytology was clearly suggestive of colloidal nodular goiter. Partial thyroidectomy was advised due to cosmetic reasons. The fear of surgery brought the patient to RRI (H), Shimla for treatment. She was treated with homoeopathic medicines following holistic concepts of Homoeopathy and the result was complete disappearance of Thyroid nodule. Sulphur initiated the action and Lycopodium completed the cure.
[ABSTRACT]   Full text not available  [PDF]
  4,363 442 -
CLINICAL RESEARCH
A multicentre observational study to ascertain the role of homoeopathic therapy in Urolithiasis
VA Siddiqui, Hari Singh, Jaya Gupta, C Nayak, Vikram Singh, MN Sinha, AK Gupta, Paul Sumithran, Yogander Rai, Rajakumar , Rupali Dixit, Deepti Dewan
April-June 2011, 5(2):30-39
Study was aimed to ascertain the role of homoeopathic medicines in Urolithiasis. A prospective, multicentre observational study was conducted by Central Council for Research in Homoeopathy (CCRH) from October 2005 to January 2010 to find the usefulness of homoeopathic medicines in cases of Urolithiasis. 901 cases were screened, out of which 311 cases were enrolled and 220 cases were analyzed in this study. The symptoms pertaining to urolithiasis were assessed before and after treatment. Pain, Dysuria and Haematuria were graded from 0-3 as per severity of complaints. Calculi were graded as per Number, Size and Position of calculi. The difference between the scores was assessed by using 'Wilcoxon sign rank test' in SPSS software (ver. 16). Out of 220 cases, there was expulsion of calculi in 106 cases (single calculus in 76 cases, multiple calculi in 30 cases) and in 114 cases, calculi remained but the symptom score reduced, indicating improvement in the case. The symptom score at baseline and after treatment was analysed and found statistically significant (P<0.005). The medicines found most useful were Lycopodium clavatum in 40.9% (n=90) cases; Sulphur in 12.3% (n=27) cases; Pulsatilla nigricans in 8.2% (n=18) cases; Nux vomica in 6.2% (n=14) cases and Cantharis vesicatoria in 5.9% (n=13) cases. Treatment with homoeopathic medicines showed positive response in dissolution/expulsion of calculi. Further validation of these results is needed by conducting randomized clinical trial.
[ABSTRACT]   Full text not available  [PDF]
  1,461 494 -
CLINICAL VERIFICATION
Cassia fistula - A multicentric clinical verification study
PS Chakraborty, Subhash Kaushik, RK Ray, RP Yadav, MK Rai, Darshan Singh, AK Bhakat, VK Singh, MD John, KC Das, VG Prasad, SS Nain, Mohan Singh, PK Chandra, DK Singh, Y Rai, Pramodji Singh, Ojit Singh, A.K.N. Singh, M Shah, PK Pradhan, R Bavaskar, L Debata, SA Ali, Krishna Singh, Vikram Singh
April-June 2011, 5(2):20-29
Objectives: The primary objective was to clinically verify the symptomatology of Cassia fistula as observed during its proving conducted by the Council earlier. The secondary objective was to ascertain the clinical symptoms. Methods: In this multicentre study, a total of 129 patients from all age groups and of both sexes were drawn from the OPDs of respective institutes and units of the Council, following the inclusion and exclusion criteria as per protocol and obtaining the written consent from the patients. Their presenting signs and symptoms were recorded in a predefined case recording proforma. Special attention was paid to the circumstances of appearance of symptoms and all the physical/ mental generalsas per the homoeopathic point of view. Thereafter, on repertorizing the symptoms, if Cassia fistula was found to be the nearest similimum for the enrolled cases, it was prescribed in different potencies like 6C, 30C and 200C in ascending order, according to the need of the case and following homoeopathic principles. The progress was noted in follow up sheets to determine the effect of the medicine. Result: It was found that many of the symptoms of the proving of the drug conducted by the Council were found to be present in the patients, which were removed subsequently by the administration of the remedy and thus verified clinically. Apart from these, some additional clinical symptoms also emerged during the study, exploring the wider area of the medicine for its therapeutic use. Conclusion: Cassia fistula may be considered as a remedy for various clinical conditions like anorexia, confusion, constipation, coryza, earache, fever, headache, lethargy, nasal obstruction, pain in abdomen, sneezing, sleeplessness, stiffness of joints, arthritis, cervical pain, tonsillitis and weakness etc. The symptoms of drug proving were also amply verified by this study and the clinical symptoms revealed in the study have widened its scope for use in various therapeutic conditions.
[ABSTRACT]   Full text not available  [PDF]
  1,226 358 -
DRUG PROVING
Andrographis paniculata - A multicentric, randomized, double-blind homoeopathic pathogenetic trial
Rajpal , Vinay Kr Singh, BN Dutta, S Das, PC Mal, AK Bhakat, RK Roy, CP Chaudhary
April-June 2011, 5(2):9-14
Objective: To elicit the pathogenetic response of the drug Andrographis paniculata in homoeopathic potencies on healthy human beings. Methodology: Drug Andrographis paniculata was proved by the Central Council for Research in Homoeopathy through double-blind, randomized, placebo-controlled method. The study was conducted at three centers. The drug was proved in two potencies (6C and 30C) on 39 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses (04 doses per day for 14 days) of each potency or placebo were consumed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the Proving Masters. The data obtained from all the three centers was compiled at proving-cum-data processing cell at CCRH headquarters after de-coding. Observations: Out of the 23 provers who were on actual drug trial, 06 manifested symptoms. Drug was able to produce symptoms in both the potencies more or less related to every part of the body. Some of the symptoms have been reproved which are mentioned in different literatures after the fragmentary proving. Conclusion: New and reproved pathogenetic responses elicited during the proving trial expands the scope of use of the drug Andrographis paniculata and will benefit the research scholars and clinicians. These symptoms will carry more value when verified clinically.
[ABSTRACT]   Full text not available  [PDF]
  1,082 255 -
DRUG STANDARDISATION
Standardisation of homoeopathic drug - Aquilegia vulgaris L
HC Gupta, P Subramanian, P Padma Rao, J Raj, Santosh K Sharma
April-June 2011, 5(2):15-19
In this present investigation, drug standardization studies are undertaken for quality assurance of a homoeopathic drug Aquilegia vulgaris. In Homoeopathy, it has been reported to have clinical indications for clavus hystericus and globus hystericus in women, sleeplessness and dysmenorrhoea. To establish the drug in the system, the standardization studies are mandatory and the useful parts of the plant drug are analyzed according to the standards of Homoeopathic Pharmacopoeia of India. The pharmacognostic and physico-chemical studies of the leaf and petiole are undertaken in present study. The diagnostic macro and microscopical characters of leaf and petiole, moisture content, ash and extractive values of crude drug are presented. The formulation of mother tincture is given. Thin layer chromatography (TLC) and Ultraviolet (UV) spectrometry are also undertaken for setting the pharmacopoeial standards of the drug.
[ABSTRACT]   Full text not available  [PDF]
  887 175 -
FUNDAMENTAL RESEARCH
Putative protective effect of Cadmium chloride high diluted solution on LLC-PK1 cell intoxicated by high concentration of this same metal: An isopathic in vitro assay
Roberta Ghilosso-Bortolini, Leoni Villano Bonamin, Carla Holandino
April-June 2011, 5(2):1-8
Cadmium is an important toxic environmental heavy metal. Several studies have demonstrated that a major site of cadmium toxicity in humans and in other animals is the proximal tubule of the kidney. A well established model for nephrotoxicity is the use of in vitro technique with proximal tubule epithelial cell lines, as LLC-PK1. Herein, we have the intention to study the possible protective effect of high diluted CdCl2 solutions. In a blinding way, LLC-PK1 cells were pre-treated with high diluted Cadmium chloride in the potencies 10cH, 15cH and 20cH. After 4 days, these cells have received CdCl2 in a pre-determined toxic concentration. The cell viability was assessed by MTT assay. We have identified a protective effect of two CdCl2 high diluted solutions, 10cH and 20cH, when cells were intoxicated by sublethal CdCl2 concentration. The results indicate that probably the high dilutions have an expressive action on cells in sublethal intoxication.
[ABSTRACT]   Full text not available  [PDF]
  777 174 -
EDITORIAL
Editorial
Alok Kumar
April-June 2011, 5(2):0-0
Full text not available  [PDF]
  612 128 -
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