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   2009| January-March  | Volume 3 | Issue 1  
    Online since April 2, 2014

 
 
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DRUG PROVING
POTHOS FOETIDUS – A multicentric double blind Homoeopathic Pathogenetic Trial
R Shaw, Vikram Singh, VA Siddiqui, Rajpal , Vinay Kr. Singh, Hari Singh, PC Mal, AK Bhakat
January-March 2009, 3(1):18-22
Objective: To elicit the pharmacodynamic response of the drug Pothos foetidus on healthy human beings in non-toxic doses. Methodology: Drug was proved through a double-blind method. The study was conducted at two centres. The drug was proved in three potencies (6C, 30C and 200C) on 25 volunteers who were selected and declared apparently healthy during their pre-trial medical examination by specialists and through their routine pathological investigations. The volunteers consumed 56 doses (four doses per day for fourteen days) of each potency (6C, 30C and 200C) in three stages for a varying period. The symptoms generated during the trial period were noted by the volunteers and elaborated and cross examined by the Proving Masters. The data obtained from both the centers was compiled at proving-cum-data processing cell at CCRH headquarters after de-coding. Observations: Out of the 18 provers who were on actual drug trial, 11 manifested symptoms. Drug was able to produce symptoms in each potency more or less on every part of the body. Only a few symptoms appeared in more than one prover. Some of the symptoms have been reproved which are mentioned in the fragmentary provings published in different literatures. Conclusion: Pharmacodynamic responses, elicited (new and reproved) during the proving trial will add to the literature available on the drug and benefit the research scholars and clinicians. This also needs verification through clinical trials.
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CLINICAL VERIFICATION
FAGOPYRUM ESCULENTUM – A Multicentric Clinical Verification Study conducted by CCRH
PS Chakraborty, JP Singh, MK Rai, Pramodji Singh, AK Vichitra, A.K.N. Singh, Deepa Chakraborty, DK Singh, Hari Singh, Mohan Singh, MN Sinha, Rajpal , RK Rai, S Prakash, SD Pathak, SR Bhagat, Vikram Singh, Vijay K Paul, VK Singh, Yogendar Rai, VA Siddiqui
January-March 2009, 3(1):23-33
Fagopyrum esculentum has been used in Homoeopathy for many conditions like diarrhea, eczema, various eyes affections, headache, itching eruptions, pruritus pudenda, sore throat, tonsillitis, uvulitis, nausea, coryza and leucorrhoea. Most of these symptoms have been reconfirmed during the study and beside these styes, conjunctivitis, nasal obstruction, burning in rectum, pain in joints, boils and productive cough were also relieved by this medicine additionally while treating some other conditions and thus unfolding the hidden character of the medicine in various clinical conditions during the study. A total of 6675 patients participated in this multicentre study at various Units/Institutes under Central Council for Research in Homoeopathy to confirm the symptom of Fagopyrum esculentum, as mentioned in the homoeopathic Materia Medica.
  1,118 292 -
CLINICAL RESEARCH
An open clinical observational study on the usefulness of pre-defined homoeopathic medicines in the management of chronic sinusitis
Sunil S Ramteke, C Nayak, Vikram Singh, Praveen Oberai, Varanasi Roja
January-March 2009, 3(1):34-40
Objective: To ascertain the usefulness of 17 pre-defined homoeopathic medicines in the management of chronic sinusitis. Methods: This is an interim analysis of the open clinical observational study conducted by the Regional Research Institute (Homoeopathy), at Shimla (Himachal Pradesh) under Central Council for Research in Homoeopathy from October 2005 to March 2009. Ninety seven patients suffering from chronic sinusitis were enrolled in the study; 51 patients completed the treatment and follow up period of 6 months and were assessed using chronic sinusitis symptom score (CSSS). Seventeen pre-defined medicines in centesimal scale of potencies (30C, 200C and 1M) were prescribed. Results: Outcome assessment of patients reflects 88 % improvement in varying degrees; marked improvement in 31(61%) patients, moderate in 10 (20%) patients and mild improvement in 4 (8%) patients. Silicea, Kali bichromicum and Calcarea carbonica were frequently indicated, were prescribed in 30C & 200C potencies and improved 34 (88.23%), 6 (100%) and 7 (86%) patients respectively. Conclusion: The data of this interim analysis of the study though shows positive effects of homoeopathic medicines in patients suffering from chronic sinusitis, the outcome of the final multicentre study on this disease will help in reaching at certain conclusion.
  1,038 313 -
EXTRA MURAL RESEARCH
Double blind placebo controlled trial of Homoeopathic medicines in the management of withdrawal symptoms in Opium addicts and its alkaloid derivatives-dependents
Ajay Grover, Bharat Bhushan, Rajesh Goel
January-March 2009, 3(1):41-44
Objectives: To ascertain the efficacy of Homoeopathic medicines in the management of withdrawal symptoms in Opium addicts & its alkaloid derivatives-dependents. Methods: 169 patients addicted primarily to opium, its alkaloid derivatives either natural or synthetic (Morphine, Codeine, Heroine, Pethidine and other Narcotic etc.) were enrolled for the study between September 2002 to August 2005. Only male patients within 15 - 50 yrs of age coming to the O.P.D. were admitted and included in the study. The study was conducted at Navjyoti Drug Demand Reduction Training Institute, New Delhi. Indicated homoeopathic medicines ( on the basis of characteristic symptoms of each medicine) out of the selected six useful medicine was prescribed to manage withdrawal symptoms experienced by the enrolled patients. The medicines and placebo were coded. Approximately half of the patients were given medicines & other half received placebo. Assessment of progress made in each individual symptom was recorded for both the groups. Results: Action of medicines & placebo in relieving the withdrawal symptomatology of Opium Drug Dependents was recorded from 3rd day onward after starting the treatment. The action of each individual Homoeopathic Medicine in relieving symptoms is significantly better than that of placebo in each group in this study. Conclusion: Homoeopathic medicines have acted better in relieving the acute withdrawal symptoms than the placebo in each group. Symptoms like lachrymation, sneezing, yawning, abdominal pain, constipation, anxiety & irritability have particularly responded better to the medicine than placebo.
  1,034 213 -
CASE RECORD
Diabetic Distal Symmetric Polyneuropathy: A Case Study
Pratima Devi, Sabyasachi Biswas
January-March 2009, 3(1):45-53
The most common form of diabetic neuropathy is diabetic distal symmetric polyneuropathy. It most frequently presents with distal sensory loss. Treatment of diabetic neuropathy is unsatisfactory in modern treatment. A case of Diabetic Distal Symmetric Polyneuropathy in a 40-year-old male treated with homoeopathy is reported here. This case shows the efficacy of homoeopathic medicine, Phosphorus, in giving not only symptomatic relief to the patient but also improving the pathological findings and peripheral nerve conduction.
  1,001 236 -
DRUG STANDARDISATION
Biochemical and Haematological Evaluation of Different Potencies of Homoeopathic Drug Ricinus Communis
EN Sundaram, P Uma Maheswara Reddy, KP Singh, K.R. Janardanan Nair, Ch. Raveendar, C Nayak
January-March 2009, 3(1):6-17
Although the seeds and / or oil of R.communis have been reported to be highly toxic, these seeds are being used in nursing women to increase the flow of milk. There is therefore a need to generate data on the biochemical and haematological profiles. Four potencies (3x, 6x, 12x and 30x) of this drug were administered orally in daily doses of 0.1 ml, 0.2 ml and 0.5 ml/rat for 14 days. The biochemical and haematological profiles of animals were studied on 21st and on 28th day during post -treatment period. Preliminary studies carried out with 4 potencies of R. communis on biochemical ( serum glucose, serum cholesterol , serum triglycerides, serum total protein, serum albumin, serum urea and serum SGOT and serum SGPT levels) and on haemotological (haemoglobin, total R.B.C. and W.B.C and differential leucocytes counts) profiles showed variable effects of different potencies of R. communis but mostly within the normal range of healthy animals. Only one rat in 12x potency group showed spear/spindle shaped R.B.C. with very less haemoglobin content. Further study is needed to confirm the effect of 12x potency on haematological profiles. The effects of R. communis significantly reduced on body weights of rat while on while no apparent difference in behaviour of animals was observed during and 14 days post-treatment.
  943 182 -
FUNDAMENTAL RESEARCH
Chronic toxicological effects of high diluted solutions of Aveloz (Euphorbia tirucalli L.) on healthy mice: a preliminary study
Marcia CBN Varricchio, Cristiane Pereira, Fernanda Sales, Teresa Gomes, Elaine Daudt, Carolina Lessa Aquino, Gleyce Moreno Barbosa, Nelson Gomes, Alexandre dos Santos Pyrrho, Paulo Eduardo Mansur Hobaica, Morgana Castelo Branco, Ricardo Kuster, Carla Holandino
January-March 2009, 3(1):1-5
The latex extracted from Euphorbia tirucalli, a plant popularly known as Aveloz, is used in complementary medicine to induce tumor regression. However, as this latex has toxic effects when administered orally in ponderal doses, the present study was designed to assess the effects of high dilutions in healthy mice over a period of 18 weeks. The Aveloz latex-high diluted solutions (latex-HD) were obtained through the interaction of two processes: 1:100 dilution in mass and succussion, using ethanol 70% as a solvent, in the homeopathic dilutions of 5, 15 and 30cH, following Farmacopéia Homeopática Brasileira. Control solutions without latex were compounded (ethanolic-HD) in the same dilutions and were administered simultaneously. The animals which received latex-HD 30cH showed a significant increase in food consumption (p < 0.05) without significant difference in weight gain. In regards to water consumption, no statistical difference was shown when different Aveloz latex-HD groups were compared, apart from the group that received 1 drop of pure latex in water, which presented a significant increase (p < 0.05) in this parameter.
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EDITORIAL
Editorial
C Nayak
January-March 2009, 3(1):0-0
  719 120 -
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