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ORIGINAL ARTICLES
To evaluate the role of homoeopathic medicines as add-on therapy in patients with rheumatoid arthritis on NSAIDs: A retrospective study
Tapas K Kundu, Afroz F Shaikh, Sindhu M Jacob
January-March 2014, 8(1):24-30
DOI:10.4103/0974-7168.129674  
Background: Conventional management of Rhematiod Arthritis (RA) includes administration of Non- Steroidal Anti- Inflammatory Drugs (NSAIDs), disease modifying anti-rheumatic drugs (DMARDs) like Methotrixate and anti-tumor necrosis factor α monoclonal antibody (anti-TNFά). Gastric ulcers, bleeding and perforation are the most common known adverse reactions found associated with excessive consumption of NSAIDs. The homoeopathic system of medicine improves the general well being, that is, Quality of Life (QoL) in addition to reducing the pain and disability. Objective: To evaluate the patients with RA receiving homoeopathic medicines with respect to QoL, Disease Activity Score (DAS), Erythrocyte Sedimentation Rate (ESR), morning stiffness/pain and frequency of analgesics after homoeopathic intervention. Design: This is a retrospective analysis of the role of homoeopathic medicines in RA. Patients diagnosed as sero-positive for RA antigen receiving homeopathic medicines were analysed for DAS, QoL, frequency of analgesics, ESR and pain/morning stiffness. Materials and Methods: Ten cases testing sero-positive for RA with at least four clinical signs were evaluated from single homoeopathic Out-Patient Department (OPD) from February 2009 and February 2011. Cases were analysed to find out the role of homoeopathic constitutional similimum in people with RA. Changes in DAS, ESR, pain/morning stiffness and QoL were considered as outcome measure. Results: Homoeopathic constitutional medicines were found to reduce the intensity of pain in patients with RA (t = 4.3733, P < 0.01) along with reduction in consumption of NSAIDs (t = 2.4, P < 0.05). The DAS reduced in all 10 patients (t = 2.67, P < 0.01). The QoL was also found to improve under homoeopathic medication (t = 4.044, P < 0.01) and no further deterioration joint/disability was observed in any of the 10 patients. Mean ESR improved to 19.5 from 38.1 (t = 2.235, P < 0.05). Out of 10, 3 (30%) patients were found to be sero-negative after homoeopathic constitutional similimum. Conclusion: Homoeopathic constitutional similimum improves the QoL of patients with RA by reducing intensity of pain, limiting disability and reducing disease activity, thus causing improvement in general and disease condition in particular. It also limits the need of analgesics and DMARDs in RA.
  67,072 7,670 2
CASE REPORT
Evidence-based homoeopathy: A case of acute paraphimosis with balanitis
Chinta Raveendar, Kishan Banoth
July-September 2013, 7(3):133-136
DOI:10.4103/0974-7168.119116  
Paraphimosis occurs when the foreskin of the uncircumcised or partially circumcised male is retracted behind the glans penis, develops venous and lymphatic congestion and cannot be returned to its normal position. This urological emergency impedes blood flow to the glans penis with potential for permanent damage and gangrene. In infants and young children, paraphimosis usually results from self-manipulation by the child or inappropriate retraction of the foreskin by the caretaker in misguided attempts at cleaning. In the sexually active adolescent or adult male, intercourse is a potential precipitant. Iatrogenic paraphimosis follows cystoscopy or bladder catheterisation if the foreskin is not pulled back over the glans penis by the medical provider. This surgical intervention can be avoided through homoeopathic treatment. A case of paraphimosis with balanitis of an adolescent treated with homoeopathy is reported here. This case shows the usefulness of homoeopathic medicines, Apis mellifica, Rhus toxicodendron, Cinnabaris and Mercurius solubilis, in not only giving symptomatic relief to the patient but also restoring the foreskin completely to its normal position.
  71,415 957 -
ORIGINAL ARTICLES
A study of the effect of mother tincture of Syzygium jambolanum on metabolic disorders of Streptozotocin induced diabetic male albino rat
Soumyajit Maiti, Tushar Kanti Bera, Kausik Chatterjee, Debidas Ghosh
July-September 2014, 8(3):129-135
DOI:10.4103/0974-7168.141730  
Background: Syzygium jambolanum is widely used in Homoeopathy for treating Diabetes mellitus and its complications. Objective: To explore the remedial effects of homoeopathic mother tincture Syzygium jambolanum on metabolic disorders of Streptozotocin induced diabetic male albino rat. Materials and Methods: Serum levels of insulin, urea, uric acid, creatinine, albumin and total protein were measured as per the standard methods using specific kits. Amount of glycogen in liver and skeletal muscles, activities of antioxidant enzymes as well as content of free radical bye products in liver and kidney tissues were assessed biochemically following the standard protocol. Results: The study indicated that the treatment of mother tincture of Syzygium jambolanum in diabetic albino rats restored the body weight and significantly controlled the elevated blood glucose level as compared with the untreated group. Levels of glycogen in liver and skeletal muscle tissues were recovered by treatment with Syzygium jambolanum in diabetic rats as compared with the untreated diabetic rats. Levels of serum urea, uric acid and creatinine were increased in diabetic rats significantly as compared with the control group, which were resettled in the control group after treatment with mother tincture of Syzygium jambolanum in diabetic animals. Alongside, significant recovery in the activities of antioxidant enzymes like catalyse, peroxidase and super oxide dismutase, the levels of free radicals generated as bye products in hepatic and renal tissues were also observed in the treatment with mother tincture of Syzygium jambolanum treated diabetic animals with respect to the untreated in diabetic animals. Conclusion: The homoeopathic mother tincture of Syzygium jambolanum has therapeutic effect on metabolic disorders and oxidative injuries in Streptozotocin induced diabetic male albino rats.
  54,545 1,180 -
Effectiveness of homoeopathic therapeutics in the management of childhood autism disorder
Praful M Barvalia, Piyush M Oza, Amit H Daftary, Vijaya S Patil, Vinita S Agarwal, Ashish R Mehta
July-September 2014, 8(3):147-159
DOI:10.4103/0974-7168.141738  
Background and Objectives: Childhood autism is severe and a serious disorder. A study was conducted by Spandan holistic institute of applied Homoeopathy, Mumbai, with the objective of demonstrating the usefulness of homeopathic management in autism. Materials and Methods: Sixty autistic children of both sexes, ≤12 years were selected for this study. It was nonrandomized, self-controlled, pre and post-intervention study, wherein the initial 6 months of observation period was used as the control period and the same patients were thereafter treated for 1 year and compared with post-intervention findings. Results: The study demonstrated significant improvement of autistic features with mean change in ATEC score (ATEC 1 -pre-treatment with ATEC 5 -post-treatment) was 15.12 and ATEC mean percent change was 19.03. Statistically significant changes in ATEC scores were observed in all the quarters analyzed through repeated measures ANOVA, with F-value 135.952, P = 0.0001. An impact was observed on all core autistic features, which included communication, 12.61%, socialization, 17%, sensory awareness, 18.82%, and health and behavior, 29% (P = 0.0001). Significant improvement was observed in behavior by Autistic Hyperactivity Scale, AHS 1 36 to AHS 5 14.30 with F-value 210.599 (P = 0.0001). Outcome assessment was carried out using MANOVA, which showed statistically significant changes in post-treatment scores, P < 0.005. Total 88.34% cases showed improvement, 8.33% showed status quo, and 3.33% cases worsened. Nine out of 60 cases showed a reversal of CARS putting them into non-autistic zone, P = 0.0001. A sharp decrease (34%) in ATEC scores, in the first quarter implied positive effect of homoeopathic medicines, prescribed, as per the homoeopathic principles. Conclusion: The study has demonstrated usefulness of homoeopathic treatment in management of neuropsychological dysfunction in childhood autism disorder, which is reflected in significant reduction of hyperactivity, behavioral dysfunction, sensory impairment as well as communication difficulty. This was demonstrated well in psychosocial adaptation of autistic children.
  35,531 6,969 2
CASE REPORT
Gangrene: Five case studies of gangrene, preventing amputation through Homoeopathic therapy
Seema Mahesh, Mahesh Mallappa, George Vithoulkas
April-June 2015, 9(2):114-122
DOI:10.4103/0974-7168.159544  
Gangrene and its associated amputations are clinically challenging, but Homoeopathy offers therapy options. In this case series, 5 cases are presented, in which the homoeopathic treatment prevented amputation of a body part. Homoeopathy stimulates the body's ability to heal through its immune mechanisms; consequently, it achieves wound healing and establishes circulation to the gangrenous part. Instead of focusing on the local phenomena of gangrene pathology, treatment focuses on the general indications of the immune system, stressing the important role of the immune system as a whole. The aim was to show, through case reports, that homoeopathic therapy can treat gangrene without amputing the gangrenous part, and hence has a strong substitution for consideration in treating gangrene.
  29,032 1,646 -
ORIGINAL ARTICLES
Antidiabetic effect of Cephalandra indica Q in diabetic rats
Arindam Pal, Biswapriya B Misra, Shibendu S Das, Samiran S Gauri, Moumita Patra, Satyahari Dey
April-June 2013, 7(2):81-90
DOI:10.4103/0974-7168.116632  
Background: Diabetes mellitus is an emerging global epidemic, taking its toll in developing countries as India. Presently, the treatment for diabetes using allopathic drugs gives only a temporary relief. A combination of right medicine and potency, on other hand has given Homoeopathy a high success rate in the treatment of this disease. Objective: The aim of this study was to investigate the effects of Cephalandra indica mother tincture and potencies on blood glucose level, cholesterol level, body weight, and beta-cells of pancreatic islets of Langerhans, in streptozotocin (STZ)-induced diabetic Wistar rats. Material and Methods: Glucose uptake was monitored in mother tincture-treated mouse fibroblast cell line. Diabetes mellitus was induced by intraperitoneal injection of STZ (55 mg/kg body weight) in adult male rats. After three days of injection, diabetic rats received mother tincture orally (750 μL/kg body weight) daily for three weeks. Results: There was a significant reduction of blood glucose level, regain of body weight, and regeneration of beta-cells in the pancreas of the mother tincture-treated rats. Mother tincture-treated 3T3 cells also showed reduced uptake of glucose in comparison to normal cells. Conclusion: The present study clearly indicates a significant antidiabetic effect of Cephalandra indica and lends support for its usage as a homoeopathic medicine.
  22,979 1,031 1
EDITORIAL
Dengue epidemic: What can we offer?
Raj K Manchanda
July-September 2015, 9(3):137-140
DOI:10.4103/0974-7168.166371  
  11,903 806 1
ORIGINAL ARTICLES
Role of homoeopathic mother tinctures in rheumatoid arthritis: An experimental study
Surender Singh, Ritu Karwasra, Prerna Kalra, Rohit Kumar, Shalu Rani, Debadatta Nayak, YK Gupta
January-March 2015, 9(1):42-48
DOI:10.4103/0974-7168.154348  
Objectives: The objective of present preliminary study was to assess the anti-inflammatory, analgesic and anti-arthritic effect of some homoeopathic mother tinctures viz. Ricinus communis (RCMT), Rauwolfia serpentina (RSMT), Bellis perennis (BPMT), Curcuma longa (CLMT), Terminalia arjuna (TAMT) and Tribulus terresteris (TTMT). Materials and Methods: Paw oedema was induced by administration of 0.1ml 1% carrageenan in normal saline into right hind paw. Degree of inflammation was evaluated according to paw swelling. Arthritis was induced by Complete Freund's Adjuvant (CFA) injection in metatarsal footpad of Wistar albino rats. Result: Curcuma longa and Tribulus terresteris mother tinctures reduced hind paw swelling decreased the paw volume in Carrageenan treated rats. Thus, revealed potent activity against inflammation. All homoeopathic mother tinctures showed peripheral analgesic activities in hot plate induced thermal algesia in mice.
  10,399 1,080 1
Individualized homoeopathy versus placebo in essential hypertension: A double-blind randomized controlled trial
Subhranil Saha, Munmun Koley, Seikh Intaj Hossain, Malay Mundle, Shubhamoy Ghosh, Goutam Nag, Achintya Kumar Datta, Prasanta Rath
April-June 2013, 7(2):62-71
DOI:10.4103/0974-7168.116629  
Background: Hypertension is the most common cardiovascular disorder posing a major public health challenge to the population. Homoeopathy, although widely used in hypertension, is assumed to have nothing but placebo effects and its specific clinical effects are frequently ascribed as implausible. Aims: To evaluate whether individualized homoeopathy can produce any significant effect different from placebo in essential hypertension by comparing the lowering of blood pressure between groups. Settings and Design: A prospective, double-blind, randomized, placebo-controlled, parallel-arm clinical trial was conducted at the Outpatient Clinic of the Mahesh Bhattacharyya Homoeopathy Medical College and Hospital, West Bengal. Material and Methods: Out of 233 hypertensives assessed for eligibility, 150 were enrolled and randomized (verum/homoeopathy 70, control/placebo 80). A total of 18 dropped out and 132 were regular (verum 64, control 68). The outcome measures were assessed after three months and six months. Statistical Analysis: The intention-to-treat population was subjected to statistical analysis. Group differences were tested using the χ2 test and independent t test. Repeated measure (ANOVA) was performed to compare the data of two groups obtained longitudinally at baseline, three months and six months. Results: The baseline data were not significantly different between the groups. After six months, mean Systolic Blood Pressure (SBP) reduction was 26.6 mm Hg (95% CI 21.5, 31.7) in the homoeopathy group and SBP increased by 3.6 mm Hg (95% CI -8.7, 1.5) in the placebo group. Similarly, the mean Diastolic Blood Pressure (SBP) in the homoeopathy group reduced by 11.8 mm Hg (95% CI 9.2, 14.4) and increased by 1.6 mm Hg (95% CI -3.6, 0.4) in the placebo group. Repeated measures ANOVA also showed significant difference (P=0.0001) between the groups. Natrum muriaticum, Calcarea carbonica, Sulphur, Thuja occidentalis, Nitric acid and Medorrhinum were frequently prescribed. Conclusion: Individualized homoeopathy produced a significantly different hypotensive effect than placebo.
  10,261 1,103 1
Dose-dependent effect of homoeopathic drug Zinc sulphate on plant growth using Bacopa monnieri as model system
Vivek Kumar Gupta, Jutika Rani Ray, Vishal Kumar Singh, Surya Deo Pathak, Chaturbhuja Nayak, Mahendra P Darokar
January-March 2014, 8(1):19-23
DOI:10.4103/0974-7168.129673  
Background: Zinc is one of the essential micronutrients in plants required in very low quantity for plant growth and development. In higher concentration, it is known to to reduce the rate of photosynthesis, So homoeopathic preparations tested to see it role on plan growth. Objective: To analyse the effect of homoeopathic preparation of Zinc sulphate on plants through in-vitro assay using Bacopa monnieri as a model plant system. Materials and Methods: Six homoeopathic potencies (1X to 6X) of Zinc sulphate were used on a decimal scale along with the control (MS basal agar medium). The samples were evaluated by adding fixed amount (100 μl) in the media as well as by dipping the explants in the test sample overnight. At the completion of the incubation period (14 days) the fresh and dry weight, number and length of the roots, number and length of the shoots and the number of leaves were analysed. Results: It was observed that Zinc sulphate showed growth inhibition at potencies from 1X to 5X, whereas at potency 6X, it exhibited growth promotion effect, when compared with the control. Conclusion: Homoeopathic drug (Zinc sulphate) exhibited growth promotion at higher potency (6X) and growth inhibition at lower potencies (1X to 5X) on Bacopa monneiri.
  10,583 507 -
DEBATE
Scientific method of preparing homoeopathic nosodes
Rajesh Shah
July-September 2014, 8(3):166-174
DOI:10.4103/0974-7168.141740  
Introduction: Nosodes are homoeopathic preparations sourced from biological materials such as diseased tissues, organisms, cultures (bacteria, fungi, and viruses), or parasites, or from decomposed products from humans or animals. More than forty-five major nosodes have been in use since 1830 but no clear guidelines regarding their preparation are available. Objective : To standardize the method of preparation of nosodes using modern technology and lay down clear guidelines for the same. Materials and Methods : Biological material identification such as culture of organism, separation of required pure fraction, quantification, standardization, dilutions, potentisation method, and safe use of nosodes were documented in a systematic way . Result: HIV, HCV and Mycobacterium tuberculosis nosodes were prepared using the modified method described in this article. Conclusion: The improved method of nosode preparation can pave way for laying clear guidelines for preparation of nosodes in homoeopathic pharmacopeias.
  9,625 948 4
CASE SERIES
Case studies for treatment of warts with Homoeopathy
Md Ismail Shaikh
October-December 2016, 10(4):272-278
DOI:10.4103/0974-7168.194342  
Warts are the growth of skin resulting from human papillomavirus infection. These may be single, multiple, smooth, or cauliflower-like and are generally treated by applying medicine externally or surgical excision procedure. Homoeopathy has a major role in the treatment of warts and most of the homoeopathic doctors use medicine in centesimal potencies. Five cases of warts were treated, two cases with centesimal potencies, and three cases treated with fifty millesimal potencies. Cases treated with fifty millesimal potencies responded more quickly than centesimal potencies without aggravating the complaints and without applying any external medicines. There is a possibility that fifty millesimal potencies have higher beneficial effects, in the treatment of warts, which can be explored further.
  8,289 1,351 -
CASE REPORT
Treatment of post-burn hypertrophic scar with homoeopathic medicine
Bhopal Singh Arya, Vaqar A Siddiqui, Rupali P Dixit
April-June 2013, 7(2):91-94
DOI:10.4103/0974-7168.116634  
Hypertrophic scar (HSc) is a dermal fibro proliferative disorder that occurs following trauma, inflammation, surgery, burns, and sometimes spontaneously. This is a case report of a 23 year old male with post-burn HSc after acid burn injury on his left jaw. The homoeopathic medicine Silicea was prescribed in 30 th potency on the basis of the totality of symptoms followed by repertorization; though only three doses of Silicea were prescribed at baseline during the course of treatment followed by placebo, there was a marked improvement in HSc as well as in associated complaints.
  8,777 699 -
ORIGINAL ARTICLES
Homoeopathic management of attention deficit hyperactivity disorder: A randomised placebo-controlled pilot trial
Praveen Oberai, S Gopinadhan, Roja Varanasi, Alok Mishra, Vikram Singh, Chaturbhuja Nayak
October-December 2013, 7(4):158-167
DOI:10.4103/0974-7168.123389  
Objective: To evaluate the usefulness of individualised homoeopathic medicines in treatment of Attention Deficit Hyperactivity Disorder (ADHD). Design: Randomised placebo-controlled single-blind pilot trial. Setting: Central Research Institute (Homoeopathy), Kottayam, Kerala, India from June 2009 to November 2011. Participants: Children aged 6-15 years meeting the Diagnostic Statistical Manual of mental disorders (DSM-IV) criteria for ADHD. Interventions: A total of 61 patients (Homoeopathy = 30, placebo = 31) were randomised to receive either individualised homoeopathic medicine in fifty millesimal (LM) potency or placebo for a period of one year. Outcome measures: Conner's Parent Rating Scale-Revised: Short (CPRS-R (S)), Clinical Global Impression-Severity Scale (CGI-SS), Clinical Global Impression- Improvement Scale (CGI-IS) and Academic performance. Results: A total of 54 patients (homoeopathy = 27, placebo = 27) were analysed under modified intention to treat (ITT). All patients in homoeopathy group showed better outcome in baseline adjusted General Linear Model (GLM) repeated measures ANCOVA for oppositional, cognition problems, hyperactivity and ADHD Index (domains of CPRS-R (S)) and CGI-IS at T3, T6, T9 and T12 (P = 0.0001). The mean baseline-adjusted treatment difference between groups at month 12 from baseline for all individual outcome measures favoured homoeopathy group; Oppositional (−16.4, 95% CI - 20.5 to − 12.2, P = 0.0001), Cognition problems (−15.5, 95% CI − 19.2 to − 11.8, P = 0.0001), Hyperactivity (−20.6, 95% CI − 25.6 to − 15.4, P = 0.0001), ADHD I (−15.6, 95% CI − 19.5 to − 11.6, P = 0.0001), Academic performance 14.4%, 95% CI 8.3 to 20.5, P = 0.0001), CGISS (−1.6, 95% CI − 1.9 to − 1.2, P = 0.0001), CGIIS (−1.6, 95% CI − 2.3 to -0.9, P = 0.0001). Conclusion: This pilot study provides evidence to support the therapeutic effects of individualised homoeopathic medicines in ADHD children. However, the results need to be validated in multi-center randomised double-blind placebo-controlled clinical trial.
  7,549 1,202 1
Homoeopathic management of Schizophrenia: A prospective, non-comparative, open-label observational study
Praveen Oberai, S Gopinadhan, Anita Sharma, Chaturbhuja Nayak, Kalpana Gautam
April-June 2016, 10(2):108-118
DOI:10.4103/0974-7168.183877  
Objectives: To evaluate the usefulness of homoeopathic intervention in Schizophrenia, in untreated cases and antipsychotic treatment resistant cases, to verify indications of medicines, and to assess relapse, if any. Materials and Methods: A prospective, non-comparative, open-label observational study was carried out from October 2005-September 2010 by CCRH at Central Research Institute (H), Kottayam, Kerala, India. Patients between 20 and 60 years of age, presenting with symptoms of Schizophrenia were screened for inclusion and exclusion criteria. The patients who were on antipsychotic drugs were allowed to continue the same along with homoeopathic medicine, the dose of antipsychotics was monitored by the Psychiatrist. The symptoms of each patient were repertorized, and medicine was initially prescribed in 30C potency after consulting Materia Medica. Patients were followed up for 12 months. Outcome of treatment was assessed with Brief Psychiatric Rating Scales (BPRS). Analysis was done using Statistical Package for the Social Sciences  SPSS Version 20.0. Results: Out of 188 enrolled patients, 17 cases did not complete the baseline information. Total 171 patients were analysed as per modified Intention to Treat Principle. Significant difference (P = 0.0001, P < 0.05) in the mean scores of BPRS, using paired t test was observed at end of the study. Sulphur, Lycopodium, Natrum muriaticum, Pulsatilla and Phosphorus were found to be the most useful medicines in treating schizophrenic patients. Conclusion: The study reflects the positive role of homoeopathic medicines in the management of patients suffering from schizophrenia as measured by BPRS.
  7,542 659 1
Hydroquinone: Homoeopathic Pathogenetic Trial
Rajesh Shah
April-June 2013, 7(2):47-61
DOI:10.4103/0974-7168.116621  
Background: A double-blind, randomized, placebo-controlled Homoeopathic Pathogenetic Trial (HPT/Drug Proving) of Hydroquinone was conducted, using the accepted guidelines, ethical approval and scientific documentation The potentization method was standardized. Toward enhancing the quality of HPT, the investigator proposed and evaluated the data using the Quantitative Pathogenetic Index and Qualitative Pathogenetic Index. Usable symptoms were derived from the study. The medicine was suggested for the treatment of vitiligo, based on its known toxicological effects. HPT of a new medicinal substance, using the established parameters, to evaluate symptoms in healthy volunteers was carried out using a controlled experiment. Aims: The aim of the study was to conduct a HPT using the accepted and scientific guidelines to derive clinically usable symptoms. Material and Methods: A double-blind, randomized, placebo-controlled homoeopathic pathogenetic trial was conducted in 22 volunteers (provers), out of whom 15 received Hydroquinone in 30C potency, thrice daily, for four weeks, while seven received the placebo. The volunteer's symptoms during the initial seven days of the run-in period were carefully noted, and these were used as a filter, by elimination of the same symptoms in that volunteer during the verum phase. Thorough documentation such as Informed Consent Form, approval by the Ethics Committee, laboratory investigations, and safety and ethical measures, were taken care of. The volunteers were trained to write data in the prescribed diaries which was analyzed at the end. The investigator introduced Quantitative and Qualitative Pathogenetic Indices as parameters in the evaluation of the data derived from the HPT. Results: The HPT of Hydroquinone exhibited qualitatively distinct symptoms, which could be applied in clinical practice. Safe use was documented. An anecdotal study supported the proposed efficacy of Hydroquinone for the treatment of vitiligo and further exploration could be carried out. Conclusion: The HPT of Hydroquinone brought in qualitative symptoms. It was noted that a potentized preparation could produce many functional symptoms, but could not produce degenerative pathological symptoms such as vitiligo. The preparation could be used by the profession for vitiligo on the basis of its toxicological effects, supported by the anecdotal study. The Quantitative and Qualitative Pathogenetic Indices could further be used in future HPTs as a tool.
  7,177 510 -
Evaluating the usefulness of 50 millesimal potencies in the treatment of chronic diseases - A retrospective study
S Abarna, Jayakrishnan Venugopal, T Sivaranjani, Kurian J Poruthukaren, Praveen Raj, Sucharitha Suresh
April-June 2015, 9(2):96-101
DOI:10.4103/0974-7168.159535  
Introduction: The 50 millesimal potency, is not fully utilized in our day to day practice. This retrospective study was done to reveal a new horizon for the physicians who use it occasionally and an eye opener for those who have never tried it. Aim: The aim was to evaluate the usefulness of 50 Millesimal potency of indicated medicine in the treatment of chronic diseases from a retrospective study. Materials and Methods: Cases treated with 50 Millesimal potency (LM) during January-May 2014, were screened and based on eligibility criteria, 50 cases were selected to study retrospectively. Treatment outcome was analyzed based on follow-up criteria. Data were statistically analyzed with Chi-square test in GNU PSPP Software. Results: 50 Millesimal potencies have the potential to give significant improvement (P = 0.01) in the treatment of chronic diseases. There were no cases reported with aggravation. The action of LM potency is not influenced (P = 0.97) by previously used Centesimal potency. Constitutional prescription has proved to have significant (P = 0.01) association with treatment outcome with LM potency, whereas Sector prescription (P = 0.12) does not. Irrespective of age, gender, and duration of illness, 50 Millesimal potencies act advantageously. Conclusion: The data suggest that 50 Millesimal potencies have significant beneficial effects in the treatment of chronic diseases.
  6,788 787 -
RESEARCH PROTOCOL
Homoeopathic Drug Proving: Randomised double-blind placebo-controlled trial
Central Council for Research in Homoeopathy
January-March 2015, 9(1):3-11
DOI:10.4103/0974-7168.154341  
Background: The methodology of Drug Proving has evolved considerably since the times of Dr. Hahnemann. Standardisation of a proving process and quality of proving studies has been a major consideration for research over the years. Proving guidelines have been developed by various international bodies such as Homoeopathic Pharmacopoeia Committee of United States (HPCUS), European Commission of Homoeopathy (ECH) and Liga Medicorum Homoeopathica Internationalis (LMHI). Drug proving has been a major research activity of the Central Council for Research in Homoeopathy (CCRH). CCRH had over the years devised its own methodology for drug proving. A protocol for the drug proving program of the Council has been developed by harmonising the CCRH methodology with that detailed in internationally developed guidelines. Methodology: This is a generic protocol, which will be applicable for drugs being proved by the Council. These will be multi-centric, prospective, parallel arm, randomised, double-blind, placebo-controlled studies. It is recommended to have at least 30 provers who can complete the total duration of proving. The Investigational Proving Substance (IPS) will be proved in two potencies. Inter- Prover and Intra- Prover placebo control will be maintained. Proving symptoms generated will be analysed on pre-defined criteria, and characteristic symptoms of the IPS will be identified. Discussion: The protocol aims at combining the possible methods to increase the quality and to minimize bias in the study, at the same time ensuring that the IPS is proved sufficiently to evolve a pathogenesis which can then further be subjected for appropriate clinical response in patients. The protocol is open for discussion and readers are invited to send their comments and reviews on the protocol.
  6,862 679 -
ORIGINAL ARTICLES
A multi-centric double-blind randomized homoeopathic pathogenetic trial of Gymnema sylvestre
Goutam Rakshit, JP Singh, SD Pathak, Ch Kishan Banoth, PK Chandra, Rajpal , Sujata Kumari Choudhury, Vinay Kr Singh
January-March 2013, 7(1):9-21
DOI:10.4103/0974-7168.114270  
Objective: To elicit the pathogenetic response of Gymnema sylvestre in homoeopathic potencies on apparently healthy human volunteers. Methodology: Gymnema sylvestre was proved by the Central Council for Research in Homoeopathy through double-blind placebo-controlled method. The study was carried out at four centers. The drug was proved in two potencies (6C and 30C) on 63 apparently healthy volunteers who were selected after conducting pre-trial medical examination by the medical specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses (04 doses per day for 14 days) of placebo. In the next two phases 56 doses (04 doses per day for 14 days) of each potency or placebo were consumed. The symptoms generated during the trial period were noted by the volunteers and elaborated by the proving masters. The data obtained from all the four centers was compiled at proving-cum-data processing cell at CCRH headquarters after decoding. Results: Out of 37 provers who were on actual drug trial, 16 manifested symptoms. The drug was able to produce symptoms in each potency in most of the parts of the body. Conclusion: The pathogenetic responses elicited during the drug proving trial expand the scope of use of the drug Gymnema sylvestre and will benefit the research scholars and clinicians. The generated symptoms of the drug will carry more meaning when verified clinically.
  6,776 683 2
Homoeopathic preparation of Berberis vulgaris as an inhibitor of Calcium oxalate crystallization: An in vitro evidence
Thellamudhu Ganesan, Divya Bhavani Ravi, Jyothilakshmi Vasavan, Anil Khurana, Debadatta Nayak, Kalaiselvi Periandavan
July-September 2015, 9(3):152-157
DOI:10.4103/0974-7168.166374  
Background: Berberis vulgaris is the most widely used drug in Homoeopathy for treating urolithiasis. However, its mechanism of action in alleviating its consequences remains uncertain. Objective: To explicate the potential role of Homoeopathic preparation of B. vulgaris on in vitro Calcium oxalate (CaOx) crystallization. Materials and Methods: Spectrophotometric crystallization assay was carried out, and the slopes of the nucleation (till the maximum) and aggregation (after the peak) phases were calculated using linear regression analysis, and the percentage inhibition exerted by the modifiers was calculated. Light microscopic observation of CaOx crystals formed in the presence or absence of modifiers was carried out to support the outcome with spectrophotometric crystallization assays and to ascertain the potential role of B. vulgaris in CaOx crystallization. Results: The crystallization studies performed so far signifies B. vulgaris to be a potent drug against CaOx crystallization both at the level of nucleation and aggregation. Conclusion: Our present findings add up to the experimental evidence to support the efficacy of the homeopathic preparation of the B. vulgaris in modulating the primary events of stone formation.
  6,773 563 -
A comparative study of homoeopathic medicine - Sulphur with the Multidrug therapy in the treatment of paucibacillary leprosy
D Chakraborty, P Das, AK Dinda, U Sengupta, T Chakraborty, J Sengupta
July-September 2015, 9(3):158-166
DOI:10.4103/0974-7168.166375  
Background: Substantial number of patients with paucibacillary leprosy may still have active skin lesions at the end of MD treatment because of the continuing immune responses, though this does not denote failure of treatment. A clinical trial was conducted to compare efficacy of a homoeopathic medicine with MDT for the cure of leprosy. Aim: To compare the effect of a homoeopathic medicine - Sulphur with the Multi drug in the treatment of Paucibacillary leprosy according to WHO guidelines. Materials and Methods: Out of total 90 patients enlisted, 60 confirmed Borderline Tuberculoid (BT) leprosy patients of the age 14 years to less than 60 years were registered under this trial. All the patients were allotted a precoded number, randomly and equally divided in two groups. One group was treated with Sulphur in 200 potency in liquid orally once in week for two years and the other group received Paucibacillary (PB) regimen as recommended by WHO. At the end of two years findings were corroborated. Results: The study showed that MDT therapy (PB regimen) and homoeopathic medicine were found equally effective as histopathology of skin showed no granulomatous lesion. The most significant clinical sign observed in all cases treated with Sulphur was reappearance of normal skin colour and regain of loss of sensation of the skin lesion. Conclusions: MD therapy (PB regimen) and homoeopathic medicine were found equally effective. The patients of paucibacillary leprosy could get rid of the skin symptoms if treatment with Sulphur (is also given with MDT).
  6,693 564 -
Evaluation of antiobesity activity of Fucus vesiculosus
Vishnu Priya Korukanti, Himabindu Ponnam, Butchi Raju Akondi
July-September 2013, 7(3):126-132
DOI:10.4103/0974-7168.119122  
Background and Aim: The drug Fucus vesiculosus is used in alternative system of medicine and homoeopathy, for the treatment of obesity. But in homoeopathic literature survey, we found no substantial pharmacological evidence to prove its safety and efficacy. So, the study was taken up on this drug and evaluated it on different animal models (diet-induced and chemical-induced models) of obesity. Material and Methods: Obesity was induced in adult female Wistar albino rats (100-120 g) by feeding the rats with cafeteria diet for 42 days in diet-induced model and by administration of single intraperitoneal injection of Triton X-100 in chemical-induced model. In the diet-induced model, weight of the animals was measured every week and parameters like total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and high density lipoprotein (HDL) were measured on 0, 21 and 43 days. Further, locomotor activity was assessed for all the animals on 43 rd day. On the same day, the rats were sacrificed by cervical dislocation and their organ and fat pad weights were recorded. In the chemical-induced model, the above parameters were assessed on day 0 and day 8. Results: Feeding cafeteria diet for 42 days resulted in significant increases in the body weight, TC, TG, LDL and VLDL levels and a reduction in the HDL level. Further, the locomotor activity was found to be reduced significantly. Treatment with Fucus vesiculosus significantly protected the cafeteria diet fed animals from all these changes and helped to maintain normal locomotor activity. Similar results were observed in chemical-induced obesity model also. Conclusion: Fucus vesiculosus treatment prevented the rats from becoming obese and the biochemical and physical parameters were maintained to normal levels. So, the drug Fucus vesiculosus can be taken up for further research on human subjects.
  6,287 868 -
Evaluation of safety profile of homoeopathic mother tinctures
Surender Singh, Rohit Kumar, Ritu Karwasra, Prerna Kalra, Shalu Rani, Debadatta Nayak, YK Gupta
April-June 2014, 8(2):81-86
DOI:10.4103/0974-7168.135640  
Background: Mother tinctures are commonly prescribed in day to day practice as therapeutic agents by homoeopathic practitioners. However, being the base preparation of medicines, safety of mother tinctures still remains a challenge because of the high variability of chemical components involved.The present study investigated the acute and sub-acute oral toxicity of different homoeopathic mother tinctures (Bellis perennis, Curcuma longa, Rauwolfia serpentina, Ricinnus communis, Tribulus terrestris and Terminalia arjuna) in experimental models. Methods: Toxicity studies were conducted to assess the level to which substances are toxic for humans and animals. In acute oral toxicity study, different homoeopathic mother tinctures were administered orally (a single dose of 4 ml/kg)and animals were observed for toxic symptoms till 14 days as per OECD (Organisation for Economic Co-operation and Development) - 423 guidelines. For sub-acute toxicity study, 28 day oral toxicity of mother tinctures (4 ml/kg daily) was carried out according to the OECD guidelines for testing of chemicals - 407. At the end of 28 days, the animals were sacrificed and toxicity was assessed on parameters such as blood, biochemistry and histopathology. Results: Results indicate that there were no toxic symptoms observed in tested animals. Results of sub-acute toxicity study did not show any change in body weight, haematological and biochemical parameters as compared to control. The histopathological examination of kidney and liver also did not reveal any organ toxicities.
  6,297 807 1
CASE REPORT
An evidence-based case of acoustic/vestibular schwannoma
Girish Gupta, Naveen Gupta, Dileep Pandey
January-March 2015, 9(1):49-54
DOI:10.4103/0974-7168.154349  
A vestibular schwannoma, often called an acoustic neuroma/schwannoma, is a benign primary intracranial tumor of the myelin-forming cells of the vestibulo-cochlear nerve (8 th cranial nerve). This tumor arises from the Schwann cells responsible for the myelin sheath that helps keep peripheral nerves insulated. [1] Approximately, 3000 cases are diagnosed each year in the United States with a prevalence of about 1 in 100,000 worldwide. It comprises 5-10% of all intracranial neoplasms in adults. Incidence peaks in the fifth and sixth decades and both sexes are affected equally. Studies in Denmark published in 2004 show the incidence of 17.4/million. Most acoustic neuromas are diagnosed in patients between the ages of 30 and 60, and men and women appear to be affected equally. [2] The case illustrated here is a rare one of acoustic/vestibular schwannoma a surgical conditions, treated with Lycopodium, which produced improvement on both subjective and objective parameters.
  6,539 451 -
ORIGINAL ARTICLES
Clinical trial for evaluation of a Human Immunodeficiency Virus nosode in the treatment for Human Immunodeficiency Virus-Infected individuals
Rajesh Shah
January-March 2015, 9(1):25-33
DOI:10.4103/0974-7168.154345  
Introduction: Identifying the need for strengthening of the immune system, the investigator has developed new Human Immunodeficiency Virus (HIV) nosode and evaluated its effect on HIV positive individuals through a clinical trial. Methods: Standardized and the scientific method of HIV nosode preparation has been described and documented. Thirty-seven HIV-infected persons were registered for the trial, and ten participants were dropped out from the study, so the effect of HIV nosode 30C and 50C, was concluded on 27 participants under the trial. Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the viral load from 12 to 24 weeks. Similarly 9 participants (33.33%) showed an increase in the CD4+ count by 20% altogether in 12 th and 24 th week. Significant weight gain was observed at week 12 (P = 0.0206). 63% and 55% showed an overall increase in either appetite or weight. The viral load increased from baseline to 24 week through 12 week in which the increase was not statistically significant (P > 0.05). 52% (14 of 27) participants have shown either stability or improvement in CD4% at the end of 24 weeks, of which 37% participants have shown improvement (1.54-48.35%) in CD4+ count and 15% had stable CD4+ percentage count until week 24 week. 16 out of 27 participants had a decrease (1.8-46.43%) in CD8 count. None of the adverse events led to discontinuation of study. Conclusion: The study results revealed improvement in immunological parameters, treatment satisfaction, reported by an increase in weight, relief in symptoms, and an improvement in health status, which opens up possibilities for future studies.
  5,800 761 1
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