Indian Journal of Research in Homeopathy

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 14  |  Issue : 1  |  Page : 3--14

Effects of individualised homoeopathic intervention in Stage I essential hypertension: A single-blind, randomised, placebo-controlled trial


Roja Varanasi1, Raju Kolli2, Yogendra Rai3, Dubashi Ramesh4, R G. R. Kiranmayee4, G Ravi Chandra Reddy5, H Baig4, Tejaswini Patole6, Priyanka Srivastava1, Rupali Bhalaerao1, Anupriya Chaudhary1, Arvind Kumar1, V Sarathy2, GR Jayasri2, Garima Sachdeva3, Saurabh Kumar Jain3, Neha Sharma3, Sucharitha Amsole4, Amita Oinam6, Praveen Oberai1, Raj K Manchanda1 
1 Central Council for Research in Homoeopathy, New Delhi, India
2 Homoeopathic Research Institute for Disabilities, Chennai, Tamil Nadu, India
3 Dr.D.P Rastogi Central Research Institute (H), Noida, Uttar Pradesh, India
4 Drug Standardization Unit (Homoeopathy), Hyderabad, Telangana, India
5 Clinic Research Unit (Homoeopathy), Tirupati, Andhra Pradesh, India
6 Regional Research Institute (Homoeopathy), Imphal, Manipur, India

Correspondence Address:
Dr. Roja Varanasi
Central Council for Research in Homoeopathy, New Delhi
India

Background: Hypertension (HTN) is a leading risk factor for death and disability and responsible for over 1.6 million deaths in India. Clinical case reports, observational studies and randomised controlled trials show the effects of homoeopathic medicine in HTN. Objectives: The results of this study will add to the evidence of effectiveness of individualised homoeopathic medicine in Stage I HTN. Methods: A single-blind, randomised, placebo-controlled trial was undertaken from October 2013 to March 2018. The primary outcome measure was to evaluate the change in systolic blood pressure (SBP) and diastolic blood pressure (DBP) every month for 3 months. Of 2127 patients screened, 217 patients who fitted the inclusion criteria were randomised to receive either homoeopathic Q potencies (or LM potencies) plus lifestyle modification (LSM) =116 or placebo + LSM = 101. LSM included physical activity and diet as part of the treatment regimen. Analysis was by intention to treat. Results: Repeated-measure ANOVA between the groups showed statistically significant difference (Wilk lambda 0.85, F = 12.12, df = 213,P = 0.0001), in both SBP and DBP favouring Individualised Homoeopathy (IH) along with LSM. Post hoc independent t-test showed a significant mean reduction in SBP (mean difference 7.12 mm Hg, 95% confidence interval [CI] 4.72–9.53,P = 0.0001) and DBP (mean difference 5.76 mm Hg, 95% CI: 4.18–7.23,P = 0.0001) favouring Homoeopathy plus LSM group. Sulphur (n = 24), Natrum muriaticum (n = 21), Lycopodium (n = 16), Nux vomica (n = 12) and Phosphorus (n = 10) were the most useful medicines. Conclusion: IH in LM potency along with LSM was found effective over placebo along with LSM in the patients suffering from Stage I HTN. Further trials in rigorous setting are warranted.


How to cite this article:
Varanasi R, Kolli R, Rai Y, Ramesh D, Kiranmayee R G, Chandra Reddy G R, Baig H, Patole T, Srivastava P, Bhalaerao R, Chaudhary A, Kumar A, Sarathy V, Jayasri G R, Sachdeva G, Jain SK, Sharma N, Amsole S, Oinam A, Oberai P, Manchanda RK. Effects of individualised homoeopathic intervention in Stage I essential hypertension: A single-blind, randomised, placebo-controlled trial.Indian J Res Homoeopathy 2020;14:3-14


How to cite this URL:
Varanasi R, Kolli R, Rai Y, Ramesh D, Kiranmayee R G, Chandra Reddy G R, Baig H, Patole T, Srivastava P, Bhalaerao R, Chaudhary A, Kumar A, Sarathy V, Jayasri G R, Sachdeva G, Jain SK, Sharma N, Amsole S, Oinam A, Oberai P, Manchanda RK. Effects of individualised homoeopathic intervention in Stage I essential hypertension: A single-blind, randomised, placebo-controlled trial. Indian J Res Homoeopathy [serial online] 2020 [cited 2020 May 31 ];14:3-14
Available from: http://www.ijrh.org/article.asp?issn=0974-7168;year=2020;volume=14;issue=1;spage=3;epage=14;aulast=Varanasi;type=0