Indian Journal of Research in Homeopathy

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Year
: 2015  |  Volume : 9  |  Issue : 4  |  Page : 288--300

Republished: Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma


Shilpi Saha1, Bhattacharjee Pushpak1, Deblina Guha1, Kirti Kajal1, Poulami Khan1, Sreeparna Chakraborty1, Shravanti Mukherjee1, Shrutarshi Paul1, Rajkumar Manchanda2, Anil Khurana2, Debadatta Nayak2, Rathin Chakrabarty3, Gaurisankar Sa1, Tanya Das1 
1 Division of Molecular Medicine, Bose Institute, P1/12, CIT Scheme VIIM, Kolkata, India
2 Central Council for Research in Homoeopathy, 61-65 Institutional Area, Janakpuri, New Delhi, India
3 Bholanath Chakrabarty Trust, 5 Subol Koley Lane, Howrah, India

Correspondence Address:
Gaurisankar Sa
Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700 054
India
Tanya Das
Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700 054
India

Adverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphurinduced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells.


How to cite this article:
Saha S, Pushpak B, Guha D, Kajal K, Khan P, Chakraborty S, Mukherjee S, Paul S, Manchanda R, Khurana A, Nayak D, Chakrabarty R, Sa G, Das T. Republished: Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma.Indian J Res Homoeopathy 2015;9:288-300


How to cite this URL:
Saha S, Pushpak B, Guha D, Kajal K, Khan P, Chakraborty S, Mukherjee S, Paul S, Manchanda R, Khurana A, Nayak D, Chakrabarty R, Sa G, Das T. Republished: Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma. Indian J Res Homoeopathy [serial online] 2015 [cited 2020 Jul 14 ];9:288-300
Available from: http://www.ijrh.org/article.asp?issn=0974-7168;year=2015;volume=9;issue=4;spage=288;epage=300;aulast=Saha;type=0