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 Table of Contents  
CASE REPORT
Year : 2016  |  Volume : 10  |  Issue : 1  |  Page : 75-82

Homoeopathic treatment in a case of co-morbid atopic dermatitis and depressive disorder


Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Kolkata, West Bengal, India

Date of Submission18-Apr-2015
Date of Acceptance22-Feb-2016
Date of Web Publication21-Mar-2016

Correspondence Address:
Suraia Parveen
Dr. Anjali Chatterjee Regional Research Institute for Homoeopathy, Kolkata, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-7168.179145

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  Abstract 

Atopic dermatitis (AD) is a skin disease characterized by itching, typical morphology, and distribution of rash, chronic relapsing course, and personal or family history of “atopic diathesis.” Stress is an important precipitating factor of AD. Stress has also some causal link with depression. Rationale of this case report is to demonstrate the co-occurrence of AD and depression in a patient, and better improvement of AD occurs when homoeopathic treatment focuses on psychological symptoms. Here, a 38-year-old male presented with a 6-month history of eczematous skin lesions with associated symptoms of depression in the background of chronic ongoing stress. A diagnosis of AD with comorbid depression was made. He initially did not show stable improvement on homoeopathic medicine selected on the basis of totality of symptoms and miasmatic background. On changing the medicine giving more priority to psychological symptoms, he gradually showed stable improvement on both the domain of symptoms and reached remission by 3 months. Remission maintained without any recurrence over the next 3½ years. Hence, the main lesson from this case is the demonstration of importance of mental symptoms over other physical symptoms in homoeopathic treatment.

Keywords: Atopic-dermatitis, Causticum, Depression, Graphites, Homoeopathy


How to cite this article:
Parveen S. Homoeopathic treatment in a case of co-morbid atopic dermatitis and depressive disorder. Indian J Res Homoeopathy 2016;10:75-82

How to cite this URL:
Parveen S. Homoeopathic treatment in a case of co-morbid atopic dermatitis and depressive disorder. Indian J Res Homoeopathy [serial online] 2016 [cited 2019 Jul 17];10:75-82. Available from: http://www.ijrh.org/text.asp?2016/10/1/75/179145


  Introduction Top


Atopic dermatitis (AD) or atopic eczema is an inflammatory non-contagious skin disease characterized by itching, typical morphology, and distribution of rash, chronic relapsing course, and personal or family history of “atopic diathesis.” However, it varies widely in clinical presentation at different ages and places. Itching must be a constant feature which usually precedes the rash (”itch that rashes”) and it may be severe, especially at night. It is followed by inflammatory red to brownish gray-colored patches with small, raised bumps, which may leak fluid and crust over when scratched. Although the patches can occur anywhere, they most often appear on the flexural surfaces of the joints (”flexural eczema”) such as inner sides of elbows, knees, and ankles. In general, the skin is dry, scaly with cracks making it vulnerable to environmental allergens. Majority of patients have personal or family history of allergic rhinitis, conjunctivitis, and bronchial asthma giving rise to the term “atopy” or vulnerability to allergy. AD has been divided into infantile, childhood, and adulthood phases based on some characteristic clinical features. However, exact categorization may be difficult at times due to overlapping features and they often do not follow the sequential evolution. There are certain factors which worsen the course and presentation of AD. Apart from environmental factors such as staphylococcal skin infection, low humidity, high pollution, exposure to detergents, stress plays an important role as a precipitating factor. Psychological and behavioral symptoms often co-occur with AD, thus called “neurodermatitis.”[1],[2],[3]

Final etiology behind AD is thought to be epidermal barrier destruction by immune system dysregulation caused out of gene–environmental interaction.[4]

Depressive disorder is a psychiatric illness characterized by the core symptoms of low mood, reduced energy, and reduced pleasurability. There are associated symptoms of negative thoughts such as worthlessness, helplessness, hopelessness; reduced confidence, disturbed sleep with nightmares, disturbed appetite, and sexual function. All symptoms last for few weeks to months. Fourth to fifth decade of life is the most common period of occurrence of depression.[5] Stress plays a very important causative role in depression. Recently, an immune system dysregulation-based hypothesis has also been proposed for neurobiology of depression (the immune-cytokine model of depression).[6]

The World Health Organization in its International Classification of Diseases-10th revision (ICD-10) has kept dermatitis and eczema in a group of conditions (F 54), which are associated with psychological and behavioral factors, along with other conditions such as asthma and urticaria,[5] all having immune dysregulation in their background.

Literature review revealed a previous study on homoeopathic treatment of AD. In that study, prospective observation of 42 patients of AD treated with homoeopathic medicines showed a significant improvement in the percentage of skin affected areas and visual analog scales.[7] No case report or study was found on the homoeopathic treatment of comorbid AD and depression.

The aim of this article is to report the co-occurrence of these two conditions, AD and depression in a middle-aged male person in the background of ongoing stress and improvement of both the conditions on homoeopathic treatment after giving more priority to the mental symptoms.


  Case Report Top


A 38-year-old male patient presented at the Central Research Institute (H), Noida, with eczematous skin diseases for 6–7 months duration in various parts of the body. He was also suffering from disturbed sleep, low mood, anxiety, and irritability for last few months. Before coming to the institute, he was treated with allopathic medication (anti-fungal with steroidal ointment) for 1 month by a dermatologist for infectious eczematous dermatitis, at that time he got little relief for 10–15 days and after that, eczema became more vigorous than earlier and he decided to take homoeopathic treatment.

There was severe itching followed by eczematous eruptions predominantly on the mediolateral aspect of shaft of the left leg [Figure 1] and some minor lesions on both pinna and both forearm for last 6 months. After scratching, the affected parts got excoriated and ooze thin, sticky, glutinous, discharges. There was aggravation at night and amelioration from wrapping up. During this same period, he used to remain depressed, worried about his future, and weep when alone. He used to feel tired, less motivated, and unable to concentrate in professional work and forgetful and hesitant to take any decision. He was not finding pleasure even during his leisure and always feeling tensed and having reduced sexual desire. He used to feel better on consolation. His sleep was disturbed with restlessness and thoughts. He had constipation with dry, hard stool.
Figure 1: Before treatment on 10.12.2010

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Both the conditions preceded by ongoing stress in professional life for last 1 year.

There was a past history of similar skin eruptions with less itching and crusting intermittently during his early school and college days. There were recurrent gingivitis and dental caries from school days, hepatitis (2006), recurrent typhoid (1992, 2006), paratyphoid (1987), chicken pox (1989), and measles (2001).

He had no addiction and was not on any ongoing allopathic medicine.

In family history, father and paternal-grandfather had hypertension and bronchial asthma. Mother had hysterectomy for dysfunctional uterine bleeding and cholecystectomy.

The patient had short stature, fair complexion, and rough skin. His facies was depressed with anxiety and nervousness.

On examination of the skin, there were reddish brown patches with exudation, crusting, and intermittent brown bumps over wide areas on the flexor and medial aspects of the left leg back and minor rashes on lateral side of both the pinna and both the forearm. The skin was dry with rough cracks on both soles.

Other systemic examinations were normal.

Provisional diagnosis of AD was made based on itching, characteristic morphology, and distribution of eruptions, past history of similar rashes, and family history of bronchial asthma, following the guidelines of ICD-10, code L-20. A comorbid diagnosis of depressive disorder is also made based on psychological symptoms and signs.

Homoeopathic Generalities

Mental

The mental generalities were irritablity ++, impatient ++, anxious and tensive ++, depression +++ (sad, melancholic), sentimental +, weeping disposition alone +, desire to company ++, consolation gives relief +, confusion of mind +++, forgetfulness ++, and cannot concentrate on anything properly +++.

Physical

The physical generalities were thermal reaction chilly (cannot prefer winter), aversion to bathing, especially in winter +++, desire salty things + and curd +, aversion in sweets +++, milk +++, stool-constipated +++, difficult to pass stool (once daily but hard, dry, not clear). Urine-normal, perspiration-normal but offensive ++, no staining, sleep-disturbed +++, delayed initiation with different thoughts and restlessness.

Miasmatic Analysis

Miasmatic analysis of all the presenting symptoms were processed with the help of comparison of the chronic miasms, [8] which shows the mixed miasmatic with predominance of psora.

After analysis and evaluation, the characteristic symptoms were converted to relevant rubrics for repertorization as follows:

  • Sadness, mental depression
  • Confusion of mind
  • Concentration: Difficult
  • Irritability
  • Heat: Vital lack of
  • Aversion: Sweets
  • Bathing: Agg
  • Perspiration: Odor: Offensive
  • Eruption: Eczema
  • Eruption: Discharging, scratching after
  • Eruption: Discharging: Moist
  • Eruption: Discharging glutinous
  • Itching: Night
  • Constipation: Difficult stool


Repertorization was done using Kent's repertory [9] in Hompath classic M.D. software (Version 8.0) (Dr. Jawahar J Shah, Mind Technologies Pvt. Ltd, Mumbai, India, 2002).[10] and a group of medicines were found [Figure 2].
Figure 2: Repertorization software Chart 1: Hompath Classic M.D. Version 8.0[10]

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Treatment and Follow-up

After repertorial totality, miasmatic analysis and with the consultation of Materia Medica, [11],[12] Graphites was selected as the first prescription. After prescribing Graphites with higher subsequent potencies (30, 200, 1M), the skin symptoms improved for a while, but did not stabilize with no improvement in depressing symptoms for 4 months. On further relapse of skin symptoms [Figure 3] and no improvement of depressing symptoms, there was a need for a fresh case taking to achieve a new similimum for the expectation of complete cure on all domains. He was re-interrogated and re-analyzed for the characteristic symptoms, i.e., mental depression, sympathetic, aggravation from thinking, difficult to concentrate, irritability, restlessness at night, chilly patient, aversion to milk, bathing aggravation, and discharging from eczema after scratching, and constipation with difficult to pass stool were taken into consideration for repertorization. The case was repertorized using Kent's repertory in Hompath classic M.D. version 8.0 [Figure 4] and Causticum was selected.
Figure 3: During treatment on 01.04.2011

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Figure 4: Repertorization software Chart 2: Hompath Classic M.D. Version 8.0[10]

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Causticum was prescribed with increasing potencies (200-1M) in subsequent follow-up followed by placebo according to the response. On this treatment, (since 01/04/11-05/08/11), both the skin and depressing symptoms showed progressive improvement [Figure 5] and complete remission was achieved after 6 months. The patient continued the follow-up for the next 1 year (since 05/08/11-10/08/12) with no recurrence. Current update over telecommunication, showed completely recovered state [Figure 6]. In the last 2½ years, all his psychosocial stressors got relieved and he did not experience any symptoms either in skin or in psychological domain [Table 1].
Figure 5: After treatment on 08.07.2011

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Figure 6: Recent status on 01.02.2015

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Table 1: Prescription and follow-ups

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  Discussion Top


Etiopathologically, both AD and depression may have a common causal link through stress and immune system dysregulation.[4],[6] In this case, there was also a role of an ongoing stress relating to professional life. Graphites was primarily selected as first prescription on the basis of totality of symptom in 30 potency on 10/12/10. Graphites with increasing potencies (30, 200, 1M,) was prescribed following homoeopathic philosophy for 4 months since 10/12/10–31/03/11 and some improvement was found on only AD but not on any depression symptoms. Discharges of eczema and itching were reduced and gradually eczema became dry, looking better for a time being in early 3 months and relapse the skin symptoms such as eczema again worsened, itching and discharges increased with more exudation and crusting, and became more depressed. The patient's dermatological symptoms were initially showing incomplete remission and relapse on treatment with Graphites despite having given sufficient time to act. It was necessary to change the medicine which was selected on the existing totality which for curing the patient in both domains, skin symptoms (AD) as well as depression.

For selection of a new similimum, a fresh case taking was done to reconstruct the totality of symptoms. On re-interrogation, it was found that two important symptoms, “sympathetic” and “aggravation from thinking complaints” were left out in the earlier repertorization, although those symptoms were present in the patient since beginning. After evaluating the symptoms, giving the more priority to mental generals than particular skin symptoms revealed a new similimum Causticum.

Causticum 200 was prescribed on 01/04/11 and follow-up was continuing for 1.6 years which is given in detail in [Table 1]. Treatment with Causticum with increasing potencies (200, 1M) was continued from 01/04/11 for the next 6 months. Initial improvement on dermatological and depression symptoms was found with treatment by Causticum 200 and then improvement was stopped and the condition became standstill. The repetition and increasing the potencies were done according to the response following the homoeopathic philosophy. For the expectation of further improvement, the higher potency of same remedy (Causticum 1M) was prescribed on 19/05/12. It supports Kent's second prescription “if a remedy has benefitted the patient, never leave it until one or more doses of higher potency has been given.” After 6 months of this treatment, stable improvement was found in AD and depression and also complete remission was achieved in all domains. The patient continued the follow-up for next 1 year with no recurrence of skin symptoms and depression symptoms. Treatment and follow-ups with responses are given in detail in [Table 1].

This corroborates the concept of Organon of Medicine by Master Samuel Hahnemann that as per §183 - ”Whenever, therefore, the dose of the first medicine ceases to have a beneficial effect, a new examination of the disease must be instituted, the status morbi as it now is must be noted down, and a second homoeopathic remedy selected in accordance with it, which shall exactly suit the present state, and one which shall be all the more appropriate can then be found, as the group of symptoms has become larger and more complete.”[13]

Further in §184 - ”In like manner, after each new dose of medicine has exhausted its action, (”when it is no longer suitable and helpful,” in the sixth edition) the state of the disease that still remains is to be noted anew with respect to its remaining symptoms, and another homoeopathic remedy sought for, as suitable as possible for the group of symptoms now observed, and so on until the recovery is complete.”[13]

It is to be noted that Causticum is the complementary medicine of Graphites. This too corroborates the concept of second prescription of Dr. Kent in his book “ Lectures on Homoeopathic Philosophy.”[14]


  Conclusion Top


Medicine, selected on the basis of totality of characteristic symptoms and through individualization which covers the patient's miasmatic background, has the capability to cure the patient at the deeper level which leads to permanent restoration of health. Successful treatment of comorbid AD and depression by Graphites followed by Causticum, proves beyond doubt of the importance of mental symptoms than other physical symptoms in the selection of medicine and the concept by Dr. Kent's Philosophy's second prescription.

Nonrecurrence of skin complaints [Figure 5] and mental depression in past 3½ years suggests that AD with mental depression can be treated successfully through individualized homoeopathic miasmatic treatment.

Financial Support and Sponsorship

Nil.

Conflicts of Interest

There are no conflicts of interest.

 
  References Top

1.
Kanwar AJ, De D. Epidemiology and clinical features of atopic dermatitis in India. Indian J Dermatol 2011;56:471-5.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Sharma L. Diagnostic clinical features of atopic dermatitis. Indian J Dermatol Venereol Leprol 2001;67:25-7.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.
Atopic Dermatitis (eczema)-Symptoms. Searched on 7.9.2015. Available from: http://www.mayoclinic.org/diseases-conditions/eczema/basics/lifestyle-home-remedies/con-20032073. [Last accessed on 2014 07 26].  Back to cited text no. 3
    
4.
De Benedetto A, Agnihothri R, McGirt LY, Bankova LG, Beck LA. Atopic dermatitis: A disease caused by innate immune defects? J Invest Dermatol 2009;129:14-30.  Back to cited text no. 4
    
5.
World Health Organization. Classification of Mental and Behavioural Disorders, Clinical Descriptions and Diagnostic Guidelines. The International Classification of Diseases. Ver. 10. Geneva: World Health Organization; 1992.  Back to cited text no. 5
    
6.
Connor TJ, Leonard BE. Depression, stress and immunological activation: The role of cytokines in depressive disorders. Life Sci 1998;62:583-606.  Back to cited text no. 6
    
7.
Eizayaga JE, Eizayaga JI. Prospective observational study of 42 patients with atopic dermatitis treated with homeopathic medicines. Homeopathy 2012;101:21-7.  Back to cited text no. 7
    
8.
Speight P. A Comparison of the Chronic Miasms, Psora, Pseudopsora, Syphilis, Sycosis. Reprint Edition. New Delhi: B. Jain Publishers (P) Ltd.; 1998. p. 1-86.  Back to cited text no. 8
    
9.
Kent JT. Repertory of Homoeopathic Materia Medica. Reprint Edition. New Delhi: B. Jain Publishers (P) Ltd.; 2007. p. 1-1423.  Back to cited text no. 9
    
10.
Shah JJ. Hompath Classic M.D Repertory. Version 8.0. Mumbai, India: Mind Technologies Pvt. Ltd.; 2010-2011.  Back to cited text no. 10
    
11.
Boericke W. Pocket Manual of Homoeopathic Materia Medica. New Delhi: B. Jain Publishers (P) Ltd.; 2011. p. 181-4; 309-12.  Back to cited text no. 11
    
12.
Allen HC. Keynotes and Characterstics with Comparisons of Some of the Leading Remedies of The Materia Medica with Bowel Nosodes. Reprint ed. New Delhi; B. Jain Publishers (P) Ltd: 2004. p. 89-91;131-3.  Back to cited text no. 12
    
13.
Hahnemann S. Aphorism 183 & 184. Organon of Medicine. 6th ed. New Delhi: B. Jain Publishers (P) Ltd.; 2011. p. 103.  Back to cited text no. 13
    
14.
Kent JT. Second prescription. Lectures on Homoeopathic Philosophy. New Delhi: B. Jain Publishers (P) Ltd.; 2011. p. 231-41.  Back to cited text no. 14
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
 
 
    Tables

  [Table 1]



 

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