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ORIGINAL ARTICLE
Year : 2014  |  Volume : 8  |  Issue : 3  |  Page : 160-165

Homoeopathic Genus Epidemicus 'Bryonia alba' as a prophylactic during an outbreak of Chikungunya in India: A cluster -randomised, double -blind, placebo- controlled trial


1 Assistant Director (H), Scientist IV, Central Research Institute (H), Kottayam, Kerala, India
2 Research Officer (H), Scientist IV, Central Research Institute (H), Kottayam, Kerala, India
3 Former Assistant Director (H), Scientist IV, Central Research Institute (H), Kottayam, Kerala, India
4 Research Officer (H), Scientist IV, Regional Research Institute (H), Gudivada, Andhra Pradesh, India, India
5 Deputy Director, National Institute of Medical Statistics, Indian Council of Medical Research, New Delhi, India
6 Research Officer (H), Scientist I, Central Council for Research in Homoeopathy, New Delhi, India
7 Statistical Assistant, Central Council for Research in Homoeopathy, New Delhi, India
8 Research Officer (H), Scientist IV, Central Council for Research in Homoeopathy, New Delhi, India
9 Former Research Officer (H), Scientist III, Central Council for Research in Homoeopathy, New Delhi, India
10 Former Assistant Director (H), Scientist III, Central Council for Research in Homoeopathy, New Delhi, India
11 Former Director General, Central Council for Research in Homoeopathy, New Delhi, India

Correspondence Address:
Debadatta Nayak
Research Officer (H), Scientist I, Central Council for Research in Homoeopathy, 61 65, Institutional Area, Janakpuri, New Delhi 110 058
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-7168.141739

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Objective: The objective was to assess the usefulness of homoeopathic genus epidemicus (Bryonia alba 30C) for the prevention of chikungunya during its epidemic outbreak in the state of Kerala, India. Materials and Methods: A cluster- randomised, double- blind, placebo -controlled trial was conducted in Kerala for prevention of chikungunya during the epidemic outbreak in August-September 2007 in three panchayats of two districts. Bryonia alba 30C/placebo was randomly administered to 167 clusters (Bryonia alba 30C = 84 clusters; placebo = 83 clusters) out of which data of 158 clusters was analyzed (Bryonia alba 30C = 82 clusters; placebo = 76 clusters) . Healthy participants (absence of fever and arthralgia) were eligible for the study (Bryonia alba 30 C n = 19750; placebo n = 18479). Weekly follow-up was done for 35 days. Infection rate in the study groups was analysed and compared by use of cluster analysis. Results: The findings showed that 2525 out of 19750 persons of Bryonia alba 30 C group suffered from chikungunya, compared to 2919 out of 18479 in placebo group. Cluster analysis showed significant difference between the two groups [rate ratio = 0.76 (95% CI 0.14 - 5.57), P value = 0.03]. The result reflects a 19.76% relative risk reduction by Bryonia alba 30C as compared to placebo. Conclusion: Bryonia alba 30C as genus epidemicus was better than placebo in decreasing the incidence of chikungunya in Kerala. The efficacy of genus epidemicus needs to be replicated in different epidemic settings.


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